中国人胃息肉与结直肠息肉及肿瘤相关性的Meta分析

Meta-analysis of the correlation between gastric polyps and colorectal polyps or tumors in Chinese

目的:评价中国人胃息肉和结直肠息肉或肿瘤之间的相关性,为胃息肉患者是否需要进行肠镜检查提供临床指导。方法:计算机检索中国生物医学文献数据库、中国知网、万方数据、维普数据库及PubMed。搜集建库以来至2019年3月关于中国人的胃息肉与肠息肉相关性的文献,采用Stata 12.0软件对纳入的文献进行Meta分析。结果:最终纳入文献12篇,总样本量为6 779例,其中胃息肉组1 878例,对照组4 901例。与对照组相比,胃息肉组结直肠息肉和肿瘤检出率增加(OR=2.75,95%CI:2.21~3.42,P<0.001)。亚组分析显示与对照组相比,≥50岁的人群结直肠息肉和肿瘤检出率增加(OR=3.26,95%CI:2.28~4.66,P<0.001),结直肠腺瘤检出率增加(OR=3.18,95%CI:2.75~3.69,P<0.001)。结论:胃镜下有胃息肉的中国人有可能患结直肠息肉或肿瘤,尤其是结直肠腺瘤。

Objective: To evaluate the correlation between gastric polyps and colorectal polyps or tumors in Chinese, and to provide clinical guidance for patients with gastric polyps who need endoscopy. Methods:Computer retrieval of China Biology Medicine disc,CNKI,Wanfang Database,VIP database and PubMed.The literatures about the relationship between gastric polyp and intestinal polyp in Chinese from the establishment of the database to March 2019 were collected,and the included literatures were Meta analyzed by using Stata 12.0 software. Results:The total sample size was 6 779 cases,including 1 878 cases in gastric polyp group and 4 901 cases in control group. Compared with the control group,the detection rate of colorectal polyp and tumor in gastric polyp group increased(OR=2.75,95%CI:2.21-3.42,P<0.001). Compared with the control group, the detection rate of colorectal polyps and tumors in the population aged over 50 years increased(OR=3.26,95%CI:2.28-4.66,P<0.001),and the detection rate of colorectal adenomas increased(OR=3.18, 95% CI: 2.75-3.69, P<0.001). Conclusion: The Chinese who have gastric polyps under gastroscope may have colorectal polyps or tumors,especially colorectal adenomas.