宫腔镜电切术联合孕激素治疗早期子宫内膜癌的临床效果

Clinical effect of hysteroscopic electrotomy combined with progesterone in the treatment of early endometrial cancer

目的分析宫腔镜电切术联合孕激素治疗早期子宫内膜癌的临床效果。方法收集河南省人民医院2014年1月至2017年1月收治的70例子宫内膜癌患者的临床资料,根据治疗方式将其分为研究组和对照组,各35例。研究组采用宫腔镜电切术联合口服醋酸甲地孕酮(MA)治疗,对照组单纯口服MA治疗。比较两组患者的临床疗效及妊娠情况。结果研究组的完全缓解率为80.00%,复发率为17.86%,均显著优于对照组的54.29%、68.42%,差异具有统计学意义(P<0.05)。研究组的妊娠率为96.43%,显著高于对照组的68.42%,差异具有统计学意义(P<0.05);研究组的足月分娩率为85.19%,显著高于对照组的46.15%,差异具有统计学意义(P<0.05)。结论宫腔镜电切术联合孕激素治疗早期子宫内膜癌的效果优于单纯孕激素治疗,可以提高患者的妊娠成功率,且复发率较低,值得临床推广应用。

Objective To analyze the clinical effect of hysteroscopic electrotomy combined with progesterone in the treatment of early endometrial cancer.Methods The clinical data of 70 patients with endometrial cancer admitted in Henan provincial people's hospital from January 2014 to January 2017 were collected and divided into study group and contral group according to the treatment method,with 35 cases in each group.The study group was treated by hysteroscopic electrotomy combined with oral megestrol acetate(MA),while the control group was treated by oral MA alone.The clinical efficacy and pregnancy of the two groups were compared.Results The complete remission rate and recurrence rate of the study group were 80.00%and 17.86%,respectively,which were significantly better than 54.29%and 68.42%of the control group,the differences were statistically significant(P<0.05).The pregnancy rate of the study group was 96.43%,which was significantly higher than 68.42%of the control group,the difference was statistically significant(P<0.05);the full-term delivery rate of the study group was 85.19%,which was significantly higher than 46.15%of the control group,the difference was statistically significant(P<0.05).Conclusion Hysteroscopic electrotomy combined with progesterone is better than progesterone alone in the treatment of early endometrial cancer,it can improve the pregnancy success rate of patients and has a low recurrence rate,which is worthy of clinical promotion and application.