血红素加氧酶-1与自噬在肝脏缺血-再灌注损伤中的研究进展

Research progress of HO-1 and autophagy in hepatic ischemia-reperfusion injury

血红素加氧酶(HO)-1及其酶解产物可通过减轻活性氧自由基损伤、减少细胞凋亡、抑制炎症反应和维持微循环稳定等作用减轻肝脏缺血-再灌注损伤(HIRI)。自噬是细胞利用溶酶体对自身受损细胞器和大分子物质进行生物学降解的过程,被认为是在应激情况下减轻细胞损伤的适应性反应,可有效减少细胞死亡。近年来越来越多的研究表明自噬与HIRI也有着密切的关系。本文回顾了近年来国内外的研究报道,从HO-1与HIRI、自噬与HIRI、HO-1与自噬在HIRI中的相互作用及其机制等方面进行综述。

Heme oxygenase(HO)-1 and its enzymolysis products can mitigate hepatic ischemia-reperfusion injury(HIRI)by alleviating the damage of reactive oxygen free radicals,mitigating cell apoptosis,inhibiting inflammatory reaction and maintaining microcirculation stability.Autophagy is a process in which the cells utilize lysosomes to degrade their damaged organelles and macromolecular substances.It is considered as an adaptive response to alleviate cell damage under stress,which can effectively reduce cell death.In recent years,more and more studies have demonstrated that autophagy is also significantly correlated with HIRI.This article reviewed recent research progresses at home and abroad on HO-1 and HIRI,autophagy and HIRI,the interaction and mechanism between HO-1 and autophagy in HIRI.