多种生物标志物在脓毒症诊断及预后评估中的应用及研究进展

Application and research progress of multiple biomarkers in diagnosis and prognosis evaluation of sepsis

脓毒症是宿主对感染的反应失调而导致的致命性器官功能障碍,具有起病急、进展快、病死率高等特点,早期确诊是保证脓毒症疗效的关键。文章结合脓毒症相关机制,阐述C反应蛋白(C-reactive protein,CRP)、血清降钙素原(procalcitonin,PCT)、血清淀粉样蛋白A(serum amyloid A,SSA)及可溶性髓样细胞触发受体-1(soluble myeloid cells trigger receptor 1,sTREM-1)等常用生化标志物在脓毒症早期诊断、预后评估中的应用价值。

Sepsis is a fatal organ dysfunction caused by the imbalance of host response to infection. It is characterized by acute onset, rapid progression and high mortality. Early diagnosis is the key to ensuring the efficacy of sepsis. In combination with sepsis-related mechanisms, this article reviewed the application values of the following common biochemical markers in the early diagnosis and prognosis evaluation of sepsis, including C-reactive protein(CRP), serum procalcitonin(PCT), serum amyloid A protein(SSA) and soluble myeloid cell trigger receptor 1(sTREM-1).