水凝胶在肿瘤免疫治疗中的研究进展

Research progress of hydrogel in tumor immunotherapy

近年来,免疫疗法在癌症治疗领域受到了极大的关注,联合治疗已经产生了良好的临床治疗效果。然而,患者对免疫治疗的反应率仍然不高,这需要注意肿瘤部位的药物利用率和全身性副作用。水凝胶作为载药平台具有极大的优点,可将抗肿瘤药物直接递送至肿瘤部位,降低全身毒性,并具有良好的可降解性。本篇综述报道了基于水凝胶平台的药物输送系统的新进展,包括免疫化学治疗、免疫放疗和免疫光热治疗等多种免疫治疗联合治疗。

Cancer immunotherapy has gained increasing attentionin recent years,with combination therapy producing good clinical therapeutic effects.However,the response rate of patients to immunotherapy is still not high,which requires attention to drug utilization and systemic side effects at tumor sites.As a drug-loading platform,hydrogel has great advantages,which can directly deliver anti-tumor drugs to tumor sites,reduce systemic toxicity,and have good degradability.In this review,the latest advances in drug delivery systems based on hydrogel platforms are summarized,including immunochemotherapy,immunoradiotherapy and immunophotothermal therapy.