过敏性紫癜病情与免疫球蛋白及T淋巴细胞亚群水平的相关性研究

Research on the relationship between the anaphylactoid purpura and the levels of immunoglobulin and T lymphocyte subsets

目的探讨过敏性紫癜患儿病情与免疫球蛋白及T淋巴细胞亚群水平的相关性。方法收集2017年11月至2019年2月来我院进行治疗的90例过敏性紫癜(HSP)患儿的临床资料,作为观察组。选取同时期来我院进行健康体检的健康志愿儿童90例为对照组。观察免疫球蛋白水平、各组T淋巴细胞亚群及NK细胞阳性百分率、相关性。结果重度组IgA、IgG、IgM水平最高,中度组次之,轻度组最低,但都高于对照组,组间对比,差异显著(P <0.05);重度组CD3+T、CD4+T、CD4+T/CD8+T、NK细胞阳性百分率水平最低,CD8+T水平最高,组间对比,差异显著(P <0.05);血清IgA水平、CD8+T水平,和HSP症状表现为正相关,r=0.618、0.591,P <0.05;CD3+T、CD4+T、CD4+T/CD8+T、NK细胞阳性百分率水平,和HSP症状表现为负相关,r=-0.612、-0.588、-0.579、-0.599,P <0.05。结论过敏性紫癜患儿病情与免疫球蛋白及T淋巴细胞亚群水平有相关性,临床可根据这些指标的变化,辅助临床诊断。

Objective To investigate the relationship between the anaphylactoid purpura and the levels of immunoglobulin and T lymphocyte subsets. Methods The clinical data of 90 children with anaphylactoid purpura who were treated in our hospital from November 2017 to February 2019 were collected as the observation group, and the control group consisted of 90 healthy children who came to our hospital for physical examination at the same time. The levels of immunoglobulin, T lymphocyte subsets and positive rate of NK cells were detected and to analyze the relationship. Results The levels of IgA, IgG and IgM were the highest in severe group, the second in moderate group and the lowest in mild group, but they were all higher than those in control group. There were significant differences between the groups(P<0.05). The positive percentage of CD3+T, CD4+T, CD4+T/CD8+T and NK cells in severe group was the lowest, and the level of CD8+T was the highest, the difference was significant(P<0.05). Serum IgA level and CD8+T level were positively correlated with HSP symptoms, r=0.618,0.591,P<0.05;positive percentage of CD3+T,CD4+T,CD4+T/CD8+T,NK cells were negatively correlated with HSP symptoms, r=-0.612,-0.588,-0.579,-0.599, P<0.05. Conclusion There is a correlation between the condition of children with anaphylactoid purpura and the levels of immunoglobulin and T-lymphocyte subsets, which can assist clinical diagnosis.