药物配合手术治疗布氏杆菌性脊柱炎临床疗效观察

Clinical Effect of Combined Pharmacotherapy with Surgical Treatment for Treating Brucellar Spondylitis

目的观察药物配合手术治疗布氏杆菌性脊柱炎的临床疗效。方法笔者医院2009年5月~2014年5月收治78例布氏杆菌性脊柱炎患者,回顾性分析其临床表现及影像学特点,均给以联合药物治疗,采用数字法随机分成两组,其中对照组(n=46)给以联合药物治疗,治疗组(n=32)在联合药物治疗基础上采用手术治疗。结果78例患者均表现为发热、多汗及腰部疼痛,经治疗后,治疗组在治疗后1年、2年随访治愈率优于对照组(P<0.05),VAS、Oswestry功能障碍指数评分均低于对照组(P<0.05)。结论根据临床表现、实验室检查及影像学特点可明确诊断,布氏杆菌性脊柱炎在联合药物治疗基础上,对符合手术指征的患者采取手术治疗可取得较好的临床疗效。

Objective To observe the clinical effect of combined pharmacotherapy with surgical treatment for treating brucellar spondylitis.Methods The patients of brucellar spondylitis undergoing the surgical treatment were based on the combined pharmacotherapy from May 2009 to May 2014 were reviewed retrospectively as a part of 78 cases.Their clinical presentation and inconography features were reviewed.The patients were divided into two groups according to the random number method.The control group(46 cases)were treated with combined pharmacotherapy,and the treatment group were treated by combined pharmacotherapy with surgical.Results Fever,hyperhidrosis and lumbodynia were noted in all cases.After 1 year and 2 years of treatment,the cure rate in observation groups were obviously higher than that of control group(P<0.05).The score of VAS and Oswestry were much lower than those of control group(P<0.05).Conclusion Brucellar spondylitis with characterized clinical manifestations,laboratory findings and radiographic features,can be treated successfully by combination of pharmacotherapy and surgical treatment,and the patients have operation indication.