外周血淋巴细胞亚群CRP及维生素D3水平与儿童反复呼吸道感染的关系

Relationship between lymphocyte subsets, CRP and vitamin D3 levels in peripheral blood and recurrent respiratory tract infection in children

目的探讨外周血淋巴细胞亚群、C反应蛋白(CRP)及维生素D3水平与儿童反复呼吸道感染的关系。方法回顾性分析我院2018年1月~2018年12月收治109例反复呼吸道感染患儿作为观察组,选取同期体检的100例健康儿童资料作为健康组。比较两组儿童血清中CRP与维生素D3水平、免疫球蛋白水平、外周血淋巴细胞亚群,分析外周血淋巴细胞亚群、CRP及维生素D3水平之间相关性。结果观察组儿童血清中CRP水平显著高于健康组(P<0.05),观察组儿童血清中维生素D3水平明显低于健康组(P<0.05);与健康组儿童比较,观察组血清中免疫球蛋白水平显著下降(P<0.05);观察组患儿CD3^+、CD4^+以及CD4^+/CD8^+均低于健康组儿童,差异均有统计学意义(P<0.05);CD3^+、CD4^+与CRP呈负相关(r=-0.635,-0.348;P<0.05),CD3^+、CD4^+与维生素D3呈正相关关系(r=0.367,0.455;P<0.05),CRP与维生素D3负相关(r=-0.319;P<0.05)。结论 CRP、维生素D3水平以及外周血淋巴细胞亚群检测可用于评估反复呼吸道感染患儿病情变化,对患儿后期治疗方案制定具有重要指导意义。

Objective To explore the relationship between the levels of lymphocyte subsets, C-reactive protein(CRP) and vitamin D3 in peripheral blood and recurrent respiratory tract infection in children. Methods A retrospective analysis was made of 109 children with recurrent respiratory tract infection admitted to our hospital from January 2018 to December 2018 as the observation group. 100 healthy children in the same period were selected as the healthy group. The levels of CRP, vitamin D3, immunoglobulin and lymphocyte subsets were compared between the two groups. The correlation among lymphocyte subsets, CRP and vitamin D3 in peripheral blood was analyzed. Results The serum CRP level in the observation group was significantly higher than that in the healthy group(P<0.05), and the serum vitamin D3 level in the observation group was significantly lower than that in the healthy group(P<0.05). Compared with the healthy group, the level of immunoglobulin in the serum of the observation group decreased significantly(P<0.05). The levels of CD3^+, CD4^+ and CD4^+/CD8^+ in the observation group were lower than those of the healthy group, the difference was statistically significant(P<0.05). CD3^+ and CD4^+ were negatively related to CRP(r=-0.635,-0.348;P<0.05). There was a positive correlation between CD 3, CD 4 and vitamin D 3(r=0.367, 0.455;P<0.05). CRP was negatively correlated with vitamin D3(r=-0.319;P<0.05). Conclusion The levels of RP, vitamin D3 and lymphocyte subsets in peripheral blood can be used to evaluate the changes of children with recurrent respiratory tract infection, which is of great guiding significance for the development of later treatment plan.