重组人表皮生长因子滴眼液联合卡波姆眼用凝胶对白内障超声乳化吸除术后干眼症患者炎症及氧化应激水平的影响

Effect of Recombinant Human Epidermal Growth Factor Eye Drops combined with Carbomer Eye Gel on inflammation and oxidative stress levels in patients with ophthalmoxerosis after phacoemulsification

目的探讨重组人表皮生长因子(rhEGF)滴眼液联合卡波姆眼用凝胶对白内障超声乳化吸除术后干眼症患者炎症及氧化应激水平的影响。方法将104例(104眼)白内障超声乳化吸除术后干眼症患者随机分为对照组和观察组,每组52例(52眼)。对照组给予玻璃酸钠滴眼液治疗,观察组采用rhEGF滴眼液和卡波姆眼用凝胶治疗,两组疗程均为4周。比较治疗前及治疗后4周两组患者的泪膜破裂时间(BUT)、基础泪液分泌Ⅰ(SIT)、角膜荧光素染色(CFS)评分、泪液中白细胞介素(IL)-1β、IL-8、丙二醛、脂质过氧化物(LPO)、超氧化物歧化酶(SOD)水平。治疗后4周评价两组患者的治疗效果。结果治疗4周后,两组患者的BUT、SIT、SOD水平均升高,CFS评分、泪液中IL-1β、IL-8、丙二醇、LPO水平均降低,且观察组患者的BUT、SIT、SOD水平均高于对照组,CFS评分、泪液中IL-1β、IL-8、丙二醇、LPO水平均低于对照组(均P<0.05);观察组患者总有效率高于对照组(P<0.05)。结论rhEGF联合卡波姆眼用凝胶治疗白内障超声乳化吸除术后干眼症的疗效显著,可有效改善患者的泪膜稳定性,抑制炎症因子水平,改善氧化应激状态。

Objective To investigate the effect of Recombinant Human Epidermal Growth Factor(rhEGF)Eye Drops combined with Carbomer Eye Gel on inflammation and oxidative stress levels in patients with ophthalmoxerosis after phacoemulsification.Methods A total of 104 patinets(104 eyes)with ophthalmoxerosis after phacoemulsification were randomly divided into control group and observation group,with 52 cases(52 eyes)in each group.The control group was given Sodium Hyaluronate Eye Drops,while the observation group was given rhEGF Eye Drops and Carbomer Eye Gel.Treatment lasted for four weeks in both groups.Before and four weeks after treatment,the two groups were compared in items of breakup time(BUT)of tear film,SchirmerⅠtest(SIT),corneal fluorescent staining(CFS)score,and tear levels of interleukin(IL)-1β,IL-8,malondialdehyde,lipid peroxide(LPO)and superoxide dismutase(SOD).The therapeutic effects of patients in the two groups were assessed four weeks after treatment.Results Four weeks after treatment,both groups exhibited elevated BUT,SIT,and SOD level,as well as decreased CFS score and tear levels of IL-1β,IL-8,malondialdehyde and LPO,furthermore,the observation group had higher BUT,SIT,and SOD level,along with lower CFS score and tear levels of IL-1β,IL-8,malondialdehyde and LPO,as compared with the control group(all P<0.05);the total effective rate in the observation group was higher than that in the control group(P<0.05).Conclusions rhEGF Eye Drops combined with Carbomer Eye Gel harbors a notable efficacy for treating ophthalmoxerosis after phacoemulsification,which can improve the stability of tear film,inhibit the levels of inflammation factors and improve oxidative stress state.