胃癌患者围手术期循环肿瘤细胞变化及其与临床病理分期的相关性

Correlation of perioperative circulating tumor cells with clinicopathologic features of gastric cancer patients

目的了解胃癌患者围手术期外周血中循环肿瘤细胞(circulating tumor cells, CTCs)数量的变化及其与肿瘤病理分期的相关性。方法应用肿瘤细胞微流控芯片技术检测手术前1天、手术后1周胃癌患者CTCs,并与其临床病理资料进行对比,阐明两者之间的相关性。结果在92例胃癌患者中,术前外周血CTCs阳性者58例,阳性率为63%;CTCs阳性的胃癌患者与肿瘤浸润深度、脉管侵犯、神经侵犯都具有相关性(P=0.02);术后1周60.5%患者CTCs消失或减少,CTCs数量没有变化甚至增多者主要见于TNM分期晚(Ⅳ期)患者。结论胃癌患者外周血中CTCs与其临床病理分期具有密切相关性。

Objective To investigate the correlation of perioperative circulating tumor cells(CTCs) with clinicopathologic features in gastric cancer patients. Methods The circulating tumor cells were detected with micro-fluid chip technique in 92 gastric cancer patients at 1 day before operation and 1 week after operation. The relationship between the CTCs and tumor clinicopathologic features of patients was analyzed. Results The positive CTCs were detected in 58 cases(63%) 1 day before operation. The positive CTCs were significantly correlated with cancer infiltration depth, blood vessel infiltration, and nerve infiltration(P=0.02). The CTCs was negative or decreased in 60.5% of patients after 1 week of operation. The CTCs were increased or not changed mainly in TNM stage Ⅳ patients. Conclusion The positive CTCs in gastric cancer patients are closely correlated with clinicopathologic features.