摘要
缺血性卒中具有高发病率、高复发率、高致残率及高死亡率的特点。通过各种手段在有效时间窗内实现再灌注至关重要。近年来的研究显示,再灌注损伤可加重病情。因此,探讨脑缺血再灌注损伤的发病机制及防治策略具有重要意义。文章对脑缺血再灌注损伤的发生机制、损伤后变化和防治进行了综述。
Ischemic stroke is characterized by high incidence,high recurrence rate,high morbidity,and high mortality.It is very important to achieve reperfusion in an effective time window by various means.Recent studies have shown that reperfusion injury can aggravate the condition.Therefore,it is of great significance to investigate the pathogenesis and prevention and treatment strategies of cerebral ischemia-reperfusion injury.This article reviews the mechanism,post-injury changes,prevention and treatment of cerebral ischemia-reperfusion injury.
作者
庄伟
陈金波
Zhuang Wei;Chen Jinbo(Department of Neurology,Binzhou Medical University Hospital,Binzhou 256600,China)
出处
《国际脑血管病杂志》
2019年第12期948-952,共5页
International Journal of Cerebrovascular Diseases
基金
山东省自然科学基金(ZR201702220320)。
关键词
卒中
脑缺血
再灌注损伤
Stroke
Brain ischemia
Reperfusion injury
