基于微型光极与超声探头的致痫灶定位方法

Positioning Method Based on Microphotodiodes and Ultrasound Transducers for Epilepsy Surgery

癫痫治疗手术往往依靠对致痫灶的准确定位,目前各种定位方式都存在着一定限制。临床上使用的脑皮层电位图(ECoG)具有很高的时间分辨率,但是其空间分辨率不能满足要求。基于人脑中存在的神经血管偶联机制,提出一种利用微型光极与微型超声探头,通过探测脑微血管血流量来进行癫痫致痫灶定位检测的新方法。动物模型实验结果表明:脑皮层表面检测到的光极信号与癫痫发作期ECoG电信号有着良好的对应关系;在脑皮层以下1 mm深度内,超声回波功率谱与ECoG电信号同样具有较好的对应关系。因此,该方法有望为临床癫痫致痫灶检测与定位提供一种新的有效手段。

Epilepsy surgery often depends on the accurate positioning of lesions;however,current positioning methods have some limitations.The electrocorticogram(ECoG)in clinical inspection has a high temporal resolution,but its spatial resolution is below the accepted standard.Based on the neurovascular coupling mechanism in the human brain,we propose a new epileptic foci detection method by detecting cerebral microvascular blood flow with microphotodiodes and ultrasound transducers.The results of experiments conducted on animals show that the light signal on the surface of the cortex has good correspondence with the ECoG signal.The spectra of the ultrasound signal also matches that of the electrical signal within a depth of 1 mm below the cortex.Therefore,we believe that this method can improve the spatial resolution of epileptic lesion detection,and it can potentially be used for depth inspection.