苦参凝胶临床应用指导意见

Guideline on clinical application of Kushen Gel

坤立舒~?苦参凝胶具有抗菌消炎的功效,是国内首个阴道用卡波姆凝胶剂。临床上常用于治疗女性下生殖道感染,其安全性和有效性得到高度认可。现代药理学研究表明,苦参凝胶及其主要成分苦参总碱具有抑菌杀虫、抗炎、抗病毒、镇痛止痒、促进黏膜修复、恢复乳杆菌增殖等药理作用。临床研究显示,苦参凝胶单用或联合其他药物治疗细菌性阴道病、外阴阴道假丝酵母菌病、滴虫阴道炎、混合性阴道炎、萎缩性阴道炎,可显著改善患者临床症状,提高疾病的治疗有效率,恢复阴道微生态,降低复发率。此外,对于宫颈人乳头瘤病毒(human papillomavirus,HPV)感染、慢性子宫颈炎患者也具有显著疗效。结合文献证据及临床专家用药经验,对苦参凝胶的药理药效研究、临床研究、临床应用及药物安全性进行归纳总结,形成苦参凝胶临床应用指导意见,以规范临床医生合理应用苦参凝胶治疗女性下生殖道感染。

Kunlishu Kushen Gel has antibacterial and anti-inflammatory effects,which is the first vaginal carbomer gel in China.It is commonly used clinically to treat female lower genital tract infections,and its safety and effectiveness have been highly recognized.Modern pharmacological studies show that Kushen Gel and its main component total matrines have pharmacological effects such as antibacterial,insecticidal,anti-inflammatory,antiviral,analgesic and antipruritic,promotion of mucosal repair and restoration of lactobacillus proliferation.Clinical studies show that Kushen Gel used alone or in combination with other drugs on the patients with bacterial vaginosis,vulvovaginal candidiasis,trichomonas vaginitis,mixed vaginitis and atrophic vaginitis,can significantly improve the clinical symptoms,enhance the therapeutic efficiency,restore the vaginal microecology and reduce the recurrence rate.In addition,it also has notable effects on patients with cervical human papillomavirus(HPV)infection and chronic cervicitis.Based on the published evidence and the experience of clinical experts,this paper summarized the pharmacology and pharmacodynamics,clinical research,clinical application and drug safety of Kushen Gel,and then formed the guideline on the clinical application of Kushen Gel,so as to standardize the rational use of Kushen Gel in the treatment of female lower genital tract infection.