心境障碍躁狂型患者血清甲状腺激素水平分析

Analysis of serum thyroid hormone levels in patients with mood disorder and mania

目的国内约10%心境障碍躁狂发作患者同时存在甲状腺功能亢进症状。本研究探讨血清甲状腺激素水平测定在心境障碍狂躁发作型患者诊断和治疗中意义。方法选取本院精神科2017-03-01-2019-02-28收治的心境障碍狂躁型患者92例作为病例组,且对该92例患者分别测定血清促甲状腺激素(thyrod stimulating hormone,TSH)、血清游离T3(serum free T3,FT3)、血清游离T4(serum free T4,FT4)。选取同期本院体检科健康体检者92名作为对照组。结果治疗前病例组TSH水平为(1.09±0.14)μIU/mL,低于对照组的(2.38±0.23)μIU/mL,t=5.486,P=0.012;病例组FT3水平为(3.75±0.33)pg/mL,高于对照组的(2.11±0.37)pg/mL,t=5.655,P=0.012;病例组FT4水平为(1.63±0.35)ng/dL,高于对照组的(0.99±0.11)ng/dL,t=5.326,P=0.014。治疗后,病例组TSH水平为(4.59±0.44)μIU/mL,较治疗前水平升高,t=4.171,P=0.010;FT3水平为(2.12±0.28)pg/mL,较治疗前水平降低,t=3.217,P=0.011;FT4水平为(0.93±0.14)ng/dL,较治疗前水平降低,t=3.820,P=0.015。结论心境障碍躁狂发作型患者血清TSH降低,FT3和FT4升高,治疗后逐渐恢复正常水平。

OBJECTIVE Studies have shown that nearly 10%of patients with mood disorder manic episode have symptoms of hyperthyroidism at the same time.This study aims to investigate the significance of serum thyroid hormone level in the diagnosis and treatment of manic episodes of mood disorder.METHODS A total of 92patients with manic mood disorder admitted to Yidu First People's Hospital from March 1,2017to February 28,019were selected as case group.Serum thyrod stimulating hormone(TSH),serum free T3(FT3)and serum free T4(FT4)were measured in 92patients.92health examinees in the physical examination department of Yidu First People's Hospital during the same period were selected as the control group.RESULTS Before treatment,the TSH level in the case group was(1.09±0.14)μIU/mL,which was lower than that of the control group(2.38±0.23)μIU/mL,t=5.486,P=0.012.The FT3level in the case group was(3.75±0.33)pg/mL,which was higher than that of the control group(2.11±0.37)pg/mL,t=5.655,P=0.012.FT4level in the case group was(1.63±0.35)ng/dL,which was higher than that of the control group(0.99±0.11),t=5.326,P=0.014.After treatment,the TSH level in the case group was(4.59±0.44)μIU/mL,which was higher than the pre-treatment level,t=4.171,P=0.010.The FT3level was(2.12±0.28)pg/mL,which was lower than the pre-treatment level,t=3.217,P=0.011.FT4level was(0.93±0.14)ng/dL,which was lower than the pre-treatment level,t=3.820,P=0.015.CONCLUSION Patients with mood disorder and manic episodes had lower serum TSH,increased FT3and FT4,and gradually returned to normal levels after treatment.