血清指标对卵巢恶性肿瘤早期诊断价值的研究进展

Advances in the value of serum index in early diagnosis of ovarian malignant tumor

在肺癌、乳腺癌、肝癌、结直肠癌、胰腺癌等多种实体恶性肿瘤方面,血清糖类抗原125(CA125)、人附睾蛋白4(HE4)、血小板与淋巴细胞的比值(PLR)和中性粒细胞与淋巴细胞的比值(NLR)已被广泛研究,其价值已被大量研究所证实,但在卵巢恶性肿瘤方面的研究较少。现有研究中发现血清CA125、HE4、PLR和NLR对卵巢恶性肿瘤的早期诊断有一定的价值,但尚无统一认识。到目前为止,关于卵巢恶性肿瘤的早期诊断仍未有公认的敏感指标,本综述的目的是对现有的证据进行总结。

For lung cancer,breast cancer,liver cancer,colorectal cancer,pancreatic cancer and many other solid malignancies,serum carbohydrate antigen 125(CA125),human epididymal protein 4(HE4),ratio of platelets to lymphocytes(PLR),and the ratio of neutrophil to lymphocytes(NLR)have been widely studied,and their value have been confirmed by a large number of studies,but there have been few studies on ovarian malignancies.Existing studies have found that serum CA125,HE4,PLR and NLR have certain value in the early diagnosis of ovarian malignant tumors,but there is no unified understanding.So far,there is no accepted sensitive indicator for the early diagnosis of ovarian malignancies.The purpose of this review is to summarize the available evidence.