2019冠状病毒病凝血和免疫功能指标的监测及临床意义

Coagulation and immune function indicators for monitoring of coronavirus disease 2019 and the clinical significance

目的:探讨凝血和免疫功能指标对2019冠状病毒病(coronavirus disease 2019,COVID-19)临床诊疗的指导意义。方法:收集2020年1至3月岳阳市一人民医院收治的所有确诊的83例COVID-19患者的一般资料,根据病情严重程度分为轻型组、普通型组、重型组和危重型组,比较各组凝血和免疫功能相关指标的差异。结果:岳阳市COVID-19发病年龄主要集中在40~65岁,各组患者的凝血功能和免疫相关指标差异均有统计学意义(均P<0.05)。结论:各型COVID-19患者的凝血和免疫功能存在一定程度异常,对临床诊治有重要的指导意义。

Objective:To explore the significance of coagulation and immune function indicators in clinical diagnosis and treatment of coronavirus disease 2019(COVID-19).Methods:All patients with COVID-19 diagnosed and treated in First People’s Hospital of Yueyang from January to March 2020 were enrolled.The general data of patients were collected.The patients were assigned into a light group(n=20),an ordinary group(n=33),a severe group(n=23),and a critically severe group(n=7)according to the severity of the disease.Coagulation and immune function indicators of each group were compared,and the relevance of coagulation and immune function indicators was analyzed.Results:The age of COVID-19 patients in Yueyang City was mainly between 45 and 65 years old.There was a significant difference in the coagulation function and immunerelated indicators in each group of patients(all P<0.05).Conclusion:There are some abnormalities in coagulation and immune function in patients with COVID-19,which possess significance for clinical diagnosis and treatment of the disease.