2000至2019年休克和脓毒症微循环领域研究进展:基于知识可视化分析

Progress of microcirculation research in shock and sepsis from 2000 to 2019 based on knowledge visualization analysis

目的:基于知识可视化分析,探讨2000至2019年休克和脓毒症微循环领域研究进展。方法:收集2000至2019年科学网(Web of Science)及万方数据收录的休克和脓毒症微循环研究领域相关文献。应用Excel软件对数据进行整理并绘制文献增长柱状图和曲线图;应用CiteSpace 5.0 R1软件对国家、研究机构、作者信息进行提取及整理并生成相关共现网络,分析该领域主要研究力量分布及合作关系;应用CiteSpace 5.0 R1软件对关键词及相关引文进行分析并绘制共被引文献网络,分析该领域前沿及热点信息。结果:共收集中文"期刊论文"与"学位论文"2000篇,英文"article"及"review"1823篇,中文文献只进行发文量、研究机构及作者的统计描述,所有英文文献均纳入可视化分析。在发文量方面,2009至2019年休克和脓毒症微循环研究领域英文文献数量呈稳步上升趋势,中文文献于2011年呈现下滑趋势;而在发文质量方面,该领域文章影响因子大多集中在6以下,高影响因子文章数量较少,且每年数量保持稳定。英文文献分析显示,全球发文量排名前3位的国家依次为德国(430篇)、美国(401篇)、荷兰(223篇)。从研究机构上看,荷兰阿姆斯特丹大学以113篇位列Web of Science首位;国内发文最多的研究机构为南方医科大学(71篇)。作者共现网络分析显示在全球形成了三大科研团体,其中以Can Ince、Daniel De Backer及Jean-Louis Vincent对该领域贡献最大。中文发文量最多的前3位作者分别是牛春雨(20篇)、赵自刚(18篇)、段美丽(13篇)。关键词共现分析显示,该领域的研究热点主要围绕在"血流""一氧化氮""失血性休克""灌注",而"心源性休克""急性肾损伤""液体复苏""舌下微循环""病死率""氧化应激"和"重症患者"等突增关键词则体现了研究前沿。共被引文献网络分析显示,"舌下微循环"和"斑点阴影分数"相关文献最为活跃,表明微循环检测技术不但是休克和脓毒症微循环研究领域的热点,更可被视为未来的新兴话题,这也与突增关键词分析结果相吻合。结论:通过知识可视化分析可以直观显示,微循环领域一直是休克和脓毒症治疗与科研的重点,其主要研究力量大多集中于欧洲发达国家,未来研究趋势多偏向于微循环监测技术。

Objective To explore the progress of microcirculation research in shock and sepsis from 2000 to 2019 based on knowledge visualization analysis.Methods The literatures related to microcirculation of shock and sepsis published in Web of Science and Wanfang databases were collected from 2000 to 2019.Then,data collected was sorted out and used to make bar charts and curves reflecting the growth trend of the literatures using Excel software.The information about country,institution and author were extracted by CiteSpace 5.0 R1 for generating co-occurring network,to find the main research power and each cooperative relation.This software was also used to analyze the related-keywords and cited reference,so that the map of co-citation reference was drawn subsequently to explore the frontiers and hot spots in this field.Results There were a total of 2000 Chinese"papers"or"dissertations",1823 English"articles"or"reviews",collected preliminarily.The Chinese literatures were only statistically described for the amounts,institutions and authors,however,all retrieved English literatures were enrolled in the visualization analysis eventually.From 2009 to 2019,the number of English literatures rose steadily;however,the number of Chinese literatures had been sliding since 2011.On terms of quality,the impact factors of most literatures were under 6,lacking high quality ones,and the number remained stable every year.According to the analysis of English literatures,the top three countries that published related papers around the world were Germany(n=430),the United States(n=401)and Netherlands(n=223).In the aspect of research institutions,the University of Amsterdam(Netherlands)ranked first in the Web of Science(n=113),while the institution in China with the most publications was the Southern Medical University(n=71).According to the analysis of co-occurring author network,there were three major globe scientific groups in which Can Ince,Daniel De Backer and Jean-Louis Vincent contributed most to this research field.The top three authors who published most Chinese papers were Niu Chunyu(n=20),Zhao Zigang(n=18)and Duan Meili(n=13).By generating the co-occurring keyword mapping,the research hot spots mainly focused on"blood flow","nitric oxide","hemorrhagic shock"and"perfusion".However,these burst keywords,including"cardiogenic shock","acute kidney injury","fluid resuscitation","sublingual microcirculation","mortality","oxidative stress",and"critically ill patient",represented the frontiers in microcirculation research of shock and sepsis field.Finally,the results of co-citation reference analysis showed that"sublingual microcirculation"and"mottling score"were most active,indicating that the research of microcirculation monitoring technology could be considered as a hot spot and also the frontier in this field,which was consistent with the results of co-occurring keywords network.Conclusions Knowledge visualization analysis can visually exhibit the hot spot and trend of microcirculation research in shock and sepsis.The power was mainly focused on a few developed countries in Europe,and the trend was more inclined to the related microcirculation monitoring technology.