摘要
单纯疱疹病毒Ⅰ型(Herpes simplex virus type 1,HSV-1)是人疱疹病毒成员,属于α-疱疹病毒亚科,可引起口唇性疱疹、疱疹性脑膜炎和疱疹性角膜炎等疾病,严重威胁人类健康。gE/gI复合物是HSV-1 gE和gI蛋白相互作用形成的多功能异源二聚体,在HSV-1生命周期的多个环节发挥重要作用。本文总结了gE/gI复合物在HSV-1病毒次级包被和释放、胞间传递及免疫逃逸过程中的功能与机制,旨在为HSV-1的防治和gE/gI复合物的深入研究提供参考。
Herpes simplex virus type Ⅰ(HSV-1)is a member of the α-herpesvirus family. It can cause herpetic meningitis and herpetic keratitis,which threaten human health. The gE/gI complex formed by the gE and gI proteins of HSV-1 is a multifunctional heterodimer which plays important roles in various aspects of the HSV-1 lifecycle. Here,we summarized the functions and mechanisms of gE/gI complex in the secondary envelopment and egress,cell-to-cell spread,and immune escape of HSV-1. In this way,we aimed to provide a reference for prevention of HSV-1 infection and in-depth study of gE/gI complex.
作者
李云娇
汪铭书
程安春
LI Yunjiao;WANG Mingshu;CHENG Anchun(Avian Disease Research Center,College of Veterinary Medicine,Sichuan Agricultural University,Wenjiang 611130,China;Institute of Preventive Veterinary Medicine,Sichuan Agricultural University,Wenjiang 611130,China;Key Laboratory of Animal Disease and Human Health of Sichuan Province,Sichuan Agricultural University,Wenjiang 611130,China)
出处
《病毒学报》
CAS
CSCD
北大核心
2020年第3期508-515,共8页
Chinese Journal of Virology
基金
“十三五”国家重点研发计划项目(项目号:2017YFD0500800),题目:水禽重要疫病免疫防控新技术研究
国家现代农业(水禽)产业技术体系专项(项目号:CARS‐42‐17),题目:免疫抑制病防控
国家农业产业技术体系四川兽药创新团队专项(项目号:SCCXTD‐2020‐18),题目:预防用生物制品研究
四川省重点研发计划(项目号:2018NZ0005),题目:现代肉鹅产业链关键技术研究集成与示范。
