11C-蛋氨酸的快速自动化合成及显像

Rapid automated synthesis of 11C-MET and the imaging of the product

目的利用新型CFN-MPS-200多功能合成模块快速合成11C-蛋氨酸(MET)并在脑胶质瘤患者体内对比显像。方法利用新型CFN-MPS-200多功能合成模块快速合成11C-MET,用HPLC和TLC测定其放化纯,并在脑胶质瘤患者体内对比显像。结果基于CFN-MPS-200多功能合成模块自动化合成11C-MET的时间约为11 min,合成产率为82±5%(衰减校正后,n=3),放化纯大于99%。产品为无色透明溶液,pH值在7.0~8.0之间,产品热源和细菌试验均合格。11C-MET在脑胶质瘤患者脑部显像具有较高的靶本比。结论利用CFN-MPS-200多功能合成模块制备11C-MET时间短,方法稳定,制备得到的11C-MET放化纯高,在脑胶质瘤患者体内显像具有较高的靶本比,能够较好的区分正常组织与病灶部位。

Objective To synthesis 11C-methionine(MET)in a rapid and automatic way,then perform 11C-MET PET/CT imaging in glioma patient.Methods We rapidly synthesized 11C-MET based on CFN-MPS-200 automatic synthesis module,and detected the radiochemical purity by HPLC and TLC.Then 11C-MET was injected into glioma patient for PET/CT imaging.Results The whole synthesis procedure consumed about 11 min.The radio chemical yield was about 82±5%(after attenuation correction,n=3)and radio chemical purity was more than 99%.The product was colorless and clear solution with pH value of 7.0-8.0.The pyrogenic reaction test and bacteria test of product was negative.11C-MET showed higher tumor/non-tumor ratio in glioma patient than 18F-FDG.Conclusion Based on CFN-MPS-200 module,we could rapidly synthesize 11C-MET with high radio chemical purity.11C-MET showed higher tumor/non-tumor ratio in glioma patient,it could differentiate tumor area and normal brain tissue clearly.