外泌体在口腔癌中的研究进展

Research Progress of Exosomes in Oral Cancer

外泌体是携带脂质、蛋白质、核酸等生物信息分子的脂质双层膜囊性小泡,介导细胞间之间的信息传递,从而在调节免疫反应、肿瘤发生发展、肿瘤浸润转移等方面发挥重要作用。口腔癌是头颈部恶性肿瘤中较为常见的一种恶性肿瘤,其发病率和死亡率逐年增高。全文综合阐述外泌体在口腔癌发生发展、浸润转移及免疫反应等过程中发挥的作用,以期为口腔癌的诊断和治疗提供新的思路。

Exosomes are lipid bilayer membrane vesicles carrying biological molecules,like lipidderivatives,proteins,DNA or RNA. Exosomes take part in the crosstalk between cells,thus exerting great influence on immunoreaction regulation,tumorigenesis,tumor invasion and metastasis.Oral cancer is one of highest incidence among all head and neck cancers,with increasing incidence and mortality rates. This article reviews the roles of exosomes in pathogenesis,invasion,metastasis and immunoreaction of oral cancer,to provide information for diagnosis and treatment of oral cancer.