通心络联合倍他乐克对冠心病稳定型心绞痛患者心功能与血脂水平的影响

Effect of Tongxinluo Combined with Betaloc on Cardiac Function and Blood Lipid Levels in Patients with Stable Angina Pectoris

目的探究通心络联合倍他乐克对冠心病稳定型心绞痛(SAP)患者心功能与血脂水平的影响。方法回顾性分析我院96例SAP患者临床资料,根据其治疗方案分为倍他乐克组(对照组47例)及通心络联合倍他乐克组(观察组49例)。记录两组临床疗效及治疗期间不良反应发生情况,并比较两组治疗前及治疗3个月后动态心电图指标[心率减速力(DC)、24小时RR间期均值的标准差(SDNN)、相邻RR间期差值均方根(RMSSD)]、超声心动图指标[左室射血分数(LVEF)、左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)]、血脂指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]差异。结果观察组临床疗效明显高于对照组(P<0.05)。两组不良反应发生情况比较,差异无统计学意义(P>0.05)。治疗3个月后,两组DC、SDNN、RMSSD及LVEF均较治疗前升高(P<0.05),且观察组高于对照组(P<0.05);LVEDD、LVESD及TC、TG、LDL-C则较治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。两组治疗前后HDL-C组间及组内比较,差异均无统计学意义(P>0.05)。结论通心络联合倍他乐克不仅能提升SAP患者心功能,还能改善患者自主神经功能,在调节血脂代谢平衡中也发挥一定作用,具有较高临床疗效及用药安全性,应用价值高。

Objective To investigate the effect of Tongxinluo combined with betaloc on cardiac function and blood lipid levels in patients with stable angina pectoris (SAP) of coronary heart disease.Methods The clinical data of 96 SAP patients in our hospital were retrospectively analyzed and divided into betaloc group (control group,n = 47) and Tongxinluo combined betaloc group (observation group,n= 49) according to their treatment plan.The clinical efficacy and the occurrence of adverse reactions during the two groups were recorded.The dynamic electrocardiogram indicators[heart rate deceleration force (DC),standard deviation of the mean value of 24 hour RR interval (SDNN),phase root mean square difference of adjacent RR intervals (RMSSD) ],echocardiographic indicators[left ventricular ejection fraction (LVEF),left ventricular end diastolic diameter (LVEDD),left ventricular end systolic diameter (LVESD) ]and blood lipid index[total cholesterol (TC),triacylglycerol (TG),low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C) ]were compared.Results The clinical efficacy of the observation group was significantly higher than that of the control group (P<0. 05).There was no statistically significant difference in the occurrence of adverse reactions between two groups (P>0. 05).After 3 months of treatment,DC,SDNN,RMSSD and LVEF in both groups were higher than before treatment (P<0. 05),and the observation group was higher than the control group (P<0. 05),LVEDD,LVESD,and TC,TG,LDL-C was lower than before treatment (P< 0. 05),and the observation group was lower than the control group (P <0. 05).There was no significant difference in HDL-C between before and after treatment between groups and within groups (P >0. 05).Conclusion Tongxinluo combined with Betaloc could not only improve the heart function of SAP patients,but also improve the autonomic nerve function of patients. Moreover,it also could play a role in regulating the balance of blood lipid metabolism which has high clinical efficacy,drug safety and application value.