观察急诊血液净化治疗重度乌头碱中毒的临床效果

Clinical Effect of Emergency Blood Purification in the Treatment of Severe Aconitine Poisoning

目的:探讨急诊血液净化治疗重度乌头碱中毒的临床效果。方法:选取2017年5月~2019年5月某院急诊收治的重度乌头碱中毒患者62例,按随机数字表法分为对照组和观察组各31例。对照组采用常规洗胃、药物对症治疗等,观察组在此基础上加用血液净化治疗,比较两组临床疗效、临床指标及不良反应。结果:观察组临床总有效率为96.77%,高于对照组的74.19%,差异有统计学意义(P<0.05);观察组治疗后心律恢复正常及住院时间分别为(11.23±5.14)h、(5.21±2.36)d,短于对照组的(21.54±8.35)h、(7.85±2.51)d,差异有统计学意义(P<0.05);观察组不良反应发生率略低于对照组,差异无统计学意义(P>0.05)。结论:急诊血液净化治疗可有效加快重度乌头碱中毒患者心律恢复,提高治疗效果,减少不良反应发生。

Objective:To investigate the clinical effect of emergency blood purification in the treatment of severe aconitine poisoning.Methods:62 patients with severe aconitine poisoning treated in a hospital from May 2017 to May 2019 were selected and divided into two groups according to the random number table method,with 31 cases in each group.The control group was treated with routine gastric lavage and drug symptomatic treatment,and the observation group was treated with blood purification based on the control group.The clinical efficacy,clinical indexes and adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.77%,which was higher than that of the control group(74.19%),the difference was statistically significant(P<0.05).The time of returning to normal cardiac rhythm and hospital stay in the observation group were(11.23±5.14)h,(5.21±2.36)d,respectively,which were shorter than those in the control group[(21.54±8.35)h,(7.85±2.51)d],and the difference was statistically significant(P<0.05).Conclusion:The incidence of adverse reactions in the observation group was slightly lower than that in the control group,and the difference was not statistically significant(P>0.05).