住院精神分裂症患者缺血性脑卒中发生风险研究

Study on the risk of ischemic stroke in inpatients with schizophrenia

目的评估住院精神分裂症患者缺血性脑卒中发生风险。方法随机收集住院精神分裂症患者和健康对照组各427例,根据患者组治疗后是否发生缺血性脑卒中将其分为精神分裂症伴脑卒中组和精神分裂症不伴脑卒中组,对其相关指标进行分析,缺血性脑卒中发生风险用改良弗明汉卒中风险评估表(M-FSP)来计算。结果与对照组相比,患者组体质指数(BMI)、收缩压(SBP)、空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、缺血性脑卒中发生风险增加,高密度脂蛋白(HDL-C)降低(P<0.05)。多因素线性回归分析示,FPG、SBP、HDL-C、吸烟指数和M-FSP总分有关联(P<0.05)。与精神分裂症不伴脑卒中组相比,精神分裂症伴脑卒中组使用氯丙嗪、氯氮平、喹硫平的患者比例更高,阿立哌唑的比例更低(P<0.05)。结论应关注住院精神分裂症患者发生缺血性脑卒中的风险。抗精神病药物可能与精神分裂症患者发生缺血性脑卒中有关联。

Objective To evaluate the risk of ischemic stroke in inpatients with schizophrenia.Methods Four hundred twenty-senven randomly selected cases of schizophrenia inpatients and 427 health controls were included in the study.The inpatients were divided into schizophrenia with stroke group and schizophrenia without stroke group according to whether they had ischemic stroke after treatment.The study analyzed their related index.The risk of ischemic stroke was assessed with the modified Framingham stroke profile(M-FSP).Results Compared with the control group,body mass index(BMI),systolic blood pressure(SBP),fasting plasma glucose(FPG),triglyceride(TG),total cholesterol(TC),the risk of ischemic stroke were higher in patient group,high density lipoprotein-cholesterol(HDL-C)was lower(P<0.05).Multivariate Linear Regression analysis demonstrated that M-FSP was correlated with FPG,SBP,HDL-C and smoking index.Compared with schizophrenia without stroke group,schizophrenia with stroke group has a higher proportion of chlorpromazine and clozapine,quetiapine,but lower proportion of aripiprazole(P<0.05).Conclusion The risk of ischemic stroke in inpatients with schizophrenia should be concerned about.Antipsychotics may be associated with ischemic stroke in patients with schizophrenia.