细胞周期蛋白依赖性激酶4/6抑制剂的研究进展

Research advances of cyclin-dependent kinase 4/6 inhibitors

细胞周期蛋白依赖性激酶(cyclin-dependent kinase, CDK)4/6通过与细胞周期蛋白D结合,参与DNA的复制和细胞分裂,控制细胞从第一个生长阶段转变至合成阶段,在细胞周期控制中起着关键作用。细胞周期蛋白D-CDK4/6-视网膜母细胞瘤蛋白信号通路的激活有助于肿瘤细胞增殖,因此CDK4/6成为抗肿瘤药物的重要作用靶点之一。本文概要介绍CDK4/6抑制剂的作用机制及其临床研究进展。

Cyclin-dependent kinase(CDK) 4/6 plays a pivotal role in the G1 to S phase of cell cycle by associating with cyclin D, participating in DNA replication and cell division. The activation of cyclin D-CDK4/6-retinoblastoma protein signaling pathway helps tumor cell proliferation, so CDK4/6 has become an important target for clinical treatment of tumors. This article mainly reviews the mechanism of action and clinical research progress of CDK4/6 inhibitors.