加替沙星加服六味地黄丸对尿路感染患者血清和尿SIL-2R与IL-8的影响

Effect of gatifloxacin plus Liuwei Dihuang pills on serum and urinary SIL-2R and IL-8 levels in patients with urinary tract infection

目的观察加替沙星加服六味地黄丸治疗尿路感染的疗效,及对血清和尿可溶性白细胞介素-2受体(SIL-2R)、白细胞介素-8(IL-8)和疗效的影响。方法选取濮阳市中医院泌尿科尿路感染患者104例为研究对象,分为治疗组和对照组,各52例。两组均口服加替沙星,每日一次。治疗组在此基础上加服六味地黄丸,每日三次。疗程均为14 d。应用酶联免疫吸附法检出两组患者血清和尿SIL-2R、IL-8,并记录两组疗效和不良反应发生率。结果治疗组患者疗效优于对照组(P=0.021);治疗组治疗后血清和尿SIL-2R、IL-8分别为(114.26±32.56)μ/ml、(66.41±22.16)pg/ml和(65.58±9.34)μ/ml、(113.28±12.21)pg/ml低于对照组(P<0.05);未发现严重不良反应。结论加替沙星加服六味地黄丸治疗尿路感染的效果较好,且可以显著改善血清和尿SIL-2R、IL-8水平。

OBJECTIVE To observe the effect of gatifloxacin plus liuwei dihuang pills on the treatment of urinary tract infection,and the effect on serum and urinary soluble interleukin 2 receptor(SIL-2 R)and interleukin 8(IL-8)levels in patients with urinary tract infection.METHODS A total of 104 patients with urinary tract infections in the urology department of Puyang Hospital of Traditional Chinese Medicine were selected as the research subjects and divided into a treatment group and a control group,with 52 cases each.Both groups were received gatifloxacin orally once daily.The treatment group was given Liuwei Dihuang Wan three times a day.The course of treatment was 14 days.Enzyme-linked immunosorbent assay was used to detect serum and urinary SIL-2 R and IL-8 in the two groups of patients,and the curative effect and incidence of adverse reactions in the two groups were recorded.RESULTS The therapeutic effect of patients in the treatment group was significantly better than the patients in the control group(P=0.021).After the treatment,serum and urine sIL-2 R and IL-8 of patients in the treatment group were(114.26±32.56)μ/ml,(66.41±22.16)pg/ml and(65.58±9.34)μ/ml,and(113.28±12.21)pg/ml,respectively,significantly lower than that those of patients in the control group(P<0.05).No serious adverse reactions were found.CONCLUSION Gatifloxacin plus Liuwei Dihuang Pill has a better effect on urinary tract infections,and can significantly improve serum and urine levels of SIL-2 R and IL-8.