慢性阻塞性肺疾病合并肌少症的机制探讨

Mechanisms linking chronic obstructive pulmonary disease and sarcopenia

肌少症是指与增龄相关的肌肉含量及功能的下降。现有研究发现与慢性阻塞性肺疾病相关的继发性肌少症会导致患者肺功能的进一步恶化及日常生活能力的下降,而这种因慢性疾病所致的炎性反应、能量消耗增加、活动耐力降低等又将加重肌少症。本文旨在初步探讨慢性阻塞性肺疾病和肌少症间可能存在的相关机制,并提倡早期干预肌少症。

Sarcopenia is a geriatric syndrome characterized by the decline in muscle mass and function associated with aging.Many studies have revealed that secondary sarcopenia associated with chronic obstructive pulmonary disease(COPD)can further reduce lung function and the ability of conducting daily living activities for the patients.Moreover,inflammation,increased energy expenditure,decreased physical endurance induced by COPD may accelerate the deterioration of sarcopenia.The aim of this review is to tentatively explore possible mechanisms linking the two diseases and promote early intervention for sarcopenia.