摘要
背景:脊髓型颈椎病是脊柱外科常见的颈椎退行性疾病,具有较高的致残率;手术减压是阻止疾病继续发展的最有效方法,然而患者术后常伴有感觉和运动功能障碍等残余神经症状,目前临床上对于脊髓型颈椎病患者术后神经功能恢复的药物治疗方案仍不明确。目的:探讨甲钴胺联合鼠神经生长因子对脊髓型颈椎病术后神经功能恢复的疗效。方法:2017年6月至2018年9月徐州医科大学附属医院收治的脊髓型颈椎病患者82例,随机分为研究组41例和对照组41例;对照组患者给予鼠神经生长因子注射液,研究组患者在对照组基础上加用甲钴胺注射液,所有患者治疗2周,分别记录2组患者术前及术后的症状和体征,利用颈椎功能障碍指数评分(Neck Disability Index,NDI)和日本骨科协会评估治疗分数量表(Japanese Orthopedic Association,JOA)进行术后神经功能评估。结果与结论:在术后1,3,6个月及1年时,两组患者的NDI评分均较术前降低(P<0.05),JOA评分均较术前升高(P<0.05);治疗6个月和1年时,研究组NDI评分显著低于对照组(P<0.05),JOA评分显著高于对照组(P<0.05)。结果表明甲钴胺联合鼠神经生长因子有助于脊髓型颈椎病患者术后神经功能的恢复,且效果优于单用鼠神经生长因子治疗。
BACKGROUND:Cervical spondylotic myelopathy is a common degenerative disease of the cervical spine in spinal surgery.Surgical decompression is the most effective method to prevent the further development of the disease.However,patients are often accompanied by residual neurological symptoms such as sensory and motor dysfunction after surgery.Currently,the drug treatment for postoperative neurological recovery of patients is still unclear clinically.OBJECTIVE:To investigate the effect of mecobalamine combined with mouse nerve growth factor on the recovery of nerve function after cervical spondylotic myelopathy surgery.METHODS:A total of 82 cases of cervical spondylotic myelopathy from June 2017 to September 2018 in the Affiliated Hospital of Xuzhou Medical University were enrolled in this study.All the patients were randomly divided into observation group and control group with 41 cases in each.Mouse nerve growth factor injection was applied to the control group,and mecobalamine injection was added to the research group.All the patients were treated for 2 weeks.The symptoms and signs in both groups were respectively recorded before and after the treatment,and postoperative residual neurological symptoms were evaluated by Neck Disability Index(NDI)scores and Japanese Orthopedic Association scores.RESULTS AND CONCLUSION:At 1 month,3 months,6 months and 1 year after the operation,the NDI scores of the two groups were lower than those before the treatment,and the JOA scores were both getting higher than those before the treatment.The NDI scores in the observation group at 6 months and 1 year after the operation were significantly lower than those in the control group,and as well,the Japanese Orthopedic Association scores were significantly higher than those in the control group.These findings indicate that the combination of mecobalamine and mouse nerve growth factor is helpful to the recovery of nerve function in patients after cervical spondylotic myelopathy surgery,and the effect is better than that of mouse nerve growth factor alone.
作者
罗选翔
经历
潘彬
冯虎
Luo Xuanxiang;Jing Li;Pan Bin;Feng Hu(Department of Orthopedics,Affiliated Hospital of Xuzhou Medical University,Xuzhou 221000,Jiangsu Province,China;Xuzhou Medical University,Xuzhou 221000,Jiangsu Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2021年第5期719-722,共4页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金(81801213),项目负责人:潘彬。
关键词
甲钴胺
因子
神经生长因子
脊髓
颈椎病
神经
周围神经
功能
mecobalamine
factor
nerve growth factor
spinal cord
cervical spondylotic myelopathy
nerve
peripheral nerve
function