银杏二萜内酯葡胺联合奥扎格雷治疗多发颅内动脉狭窄的疗效及其对患者血管内皮功能和神经功能的影响

Efficacy of ginkgo terpene lactones meglumine combined with ozagrel for treatment of multiple intracranial artery stenosis and its impact on patients'vascular endothelial function and neurological function

目的探讨银杏二萜内酯葡胺联合奥扎格雷治疗多发颅内动脉狭窄的疗效及其对患者血管内皮功能和神经功能的影响。方法将108例多发颅内动脉狭窄患者,随机分为对照组和观察组,每组54例,对照组给予奥扎格雷治疗,观察组在此基础上给予银杏二萜内酯葡胺治疗。比较两组患者治疗前、治疗后30 d血浆一氧化氮和内皮素水平、血清脂联素和过氧化氢酶水平、美国国立卫生研究院卒中量表(NIHSS)和Barthel评分,以及两组患者治疗后的临床疗效。结果治疗后,观察组患者血浆内皮素水平、NIHSS评分低于对照组,血浆一氧化氮水平、血清脂联素和过氧化氢酶水平高于对照组,疗效优于对照组(P<0.05)。结论银杏二萜内酯葡胺联合奥扎格雷治疗多发颅内动脉狭窄患者可以改善内皮功能及神经功能,提高疗效。

Objective To investigate the efficacy of ginkgo terpene lactones meglumine combined with ozagrel for the treatment of multiple intracranial artery stenosis and its impact on patients'vascular endothelial function and neurological function.Methods A total of 108 patients with multiple intracranial artery stenosis were randomly divided into control group and observation group,with 54 cases in each group.The control group received ozagrel therapy,and the observation group was treated with ginkgo terpene lactones meglumine on the basis of the therapy in the control group.The two groups were compared with respect to plasma nitric oxide and endothelin levels,serum adiponectin and catalase levels,the National Institute of Health Stroke Scale(NIHSS)score and Barthel score before treatment and 30 days after treatment,as well as clinical efficacy after treatment.Results After treatment,the observation group had lower plasma endothelin level,lower NIHSS score,higher plasma nitric oxide and serum adiponectin and catalase levels,and superior efficacy as compared with the control group(P<0.05).Conclusion Ginkgo terpene lactones meglumine combined with ozagrel can improve endothelial and neurological functions and increase efficacy in the treatment of patients with multiple intracranial artery stenosis.