老年动脉粥样硬化性脑梗死患者血清CD147、hs-CRP、CysC水平与颈动脉狭窄程度及硬度的相关性

Correlation of levels of serum CD147,hs-CRP,CysC with severity and hardness of carotid stenosis in elderly patients with atherosclerotic cerebral infarction

目的探讨老年动脉粥样硬化性脑梗死患者血清基质金属蛋白酶刺激因子147(CD147)、高敏C反应蛋白(hs-CRP)、胱抑素C(CysC)水平与颈动脉狭窄程度及硬度的相关性。方法随机抽取2016年5月至2019年5月河南科技大学第二附属医院收治的老年动脉粥样硬化性脑梗死患者150例为观察组,另抽取同期150例健康体检者为对照组。比较对照组健康体检者及观察组不同颈动脉狭窄程度、颈动脉硬化程度、动脉斑块超声分级患者的血清CysC、hs-CRP、CD147水平。结果观察组不同颈动脉狭窄程度患者血清CysC、hs-CRP、CD147水平均高于对照组(P<0.05);观察组中颈动脉重度狭窄患者血清CysC、hs-CRP、CD147水平最高,其次为中度狭窄、轻度狭窄患者,比较差异有统计学意义(P<0.05)。颈动脉硬化轻度、中度、重度患者血清CysC、hs-CRP、CD147水平比较差异有统计学意义(P<0.05)。动脉斑块超声分级1、2、3级患者血清CysC、hs-CRP、CD147水平比较差异有统计学意义(P<0.05)。结论血清CD147、hs-CRP、CysC联合检测能指导临床判断老年动脉粥样硬化性脑梗死患者动脉狭窄及硬化程度,有利于制定个性化治疗方案。

Objective To investigate the correlation of levels of serum matrix metalloproteinase stimulating factor 147(CD147),high-sensitivity C-reactive protein(hs-CRP),cystatin C(CysC)with severity and hardness of carotid stenosis in elderly patients with atherosclerotic cerebral infarction.Methods A total of 150 elderly patients with atherosclerotic cerebral infarction admitted to the Second Affiliated Hospital of Henan University of Science and Technology from May 2016 to May 2019 were randomly selected and included in the observation group.In the same period,150 healthy subjects who underwent physical examination in the hospital were selected and included in the control group.Levels of serum CysC,hs-CRP,CD147 of healthy persons in the control group and of patients with different degrees of carotid stenosis,carotid atherosclerosis,and arterial plaque ultrasound grading in the observation group were compared.Results Levels of serum CysC,hs-CRP and CD147 of patients with mild,moderate and severe carotid artery stenosis in observation group were higher than those in control group(P<0.05).The levels of CysC,hs-CRP and CD147 of patients with severe carotid artery stenosis in the observation group were the highest,followed by patients with moderate carotid artery stenosis and patients with mild moderate carotid artery stenosis(P<0.05).There were significant differences in the levels of serum CysC,hs-CRP and CD147 among patients with mild,moderate and severe carotid atherosclerosis(P<0.05).The differences in levels of serum CysC,hs-CRP and CD147 among patients with arterial plaque ultrasound grade 1,2 and 3 were statistically significant(P<0.05).Conclusions The combined detection of serum CD147,hs-CRP and CysC can guide the clinical prediction on arterial stenosis severity and atherosclerosis grading in elderly patients with atherosclerotic cerebral infarction,which is conducive to the development of personalized treatment plans.