噻托溴铵不同给药方式治疗对哮喘合并COPD患者肺功能的影响

The effect of different administration methods of tiotropium bromide on lung function in patients with asthma and COPD

目的探究噻托溴铵不同给药方式治疗对哮喘合并COPD患者肺功能的影响。方法研究样本为2018年1月~2019年12月收治的84例哮喘合并慢性阻塞性肺疾病(COPD)患者,采用数字随机表将其分为观察组和对照组,每组42例,给予观察组噻托溴铵5μg,每天1次治疗;对照组采用噻托溴铵2.5μg,每天2次治疗。对比两组患者不良反应发生率及治疗前后肺功能。结果治疗后,观察组患者FVC、RQ、PEF指标明显优于对照组(P<0.05);与对照组相比,观察组患者治疗有效率明显更高,差异有统计学意义(P<0.05);两组不良反应发生率无显著差异(P>0.05)。结论噻托溴铵在哮喘合并COPD患者治疗中具有较高的安全性,采用5μg、每天1次的给药方式,临床治疗效果更佳,有利于患者肺功能的改善,从而促使患者早日恢复,提高患者生活质量。

Objective To explore the effect of different administration methods of tiotropium bromide on lung function in patients with asthma and COPD.Methods The study sample was 84 patients with asthma combined with chronic obstructive pulmonary disease(COPD)admitted to our hospital from January 2018 to December 2019.They were divided into an observation group and a control group using a digital random table,42 cases in each group,given 5μg of tiotropium bromide in the observation group,once per day of treatment,and 2.5μg of tiotropium bromide in the control group,twice per day,once every morning and evening,comparing the incidence of adverse reactions and lungs before and after treatment.Results After treatment,the FVC,RQ and PEF indicators of the observation group were significantly better than the control group(P<0.05).Compared with the control group,the observation group had significantly higher treatment efficiency,and the difference was statistically significant;The difference in incidence was not significant(P>0.05).Conclusion Tiotropium bromide has a higher safety in the treatment of asthma with COPD patients.The administration of 5μg once a day has a better clinical treatment effect,which is conducive to the improvement of patients'lung function and thus promotes patients recover as soon as possible to improve the patient's quality of life.