经支气管镜黏膜活检后ROSE与瑞氏染色对管腔浸润型肺癌诊断的临床价值对比

A Comparative Study on Clinical Value of ROSE and Wright’s Staining after Bronchoscopy Mucosal Biopsy in the Diagnosis of Luminal Infiltrating Lung Cancer

目的:对比经支气管镜黏膜活检后快速现场评价(ROSE)与瑞氏染色对管腔浸润型肺癌诊断的临床价值。方法:选取2019年1月-2020年4月在本科行经支气管镜黏膜活检术的60例肺癌患者作为研究对象,按不同检查方法分为ROSE组(n=25)、非ROSE组(n=16)、瑞氏染色组(n=19)。比较三组管腔浸润型肺癌病检阳性率、灵敏度、特异度、并发症发生率及诊断费用。结果:ROSE组、非ROSE组、瑞氏染色组管腔浸润型肺癌病检确诊阳性所占比例分别为64.00%、31.25%和52.63%,ROSE组病检确诊阳性比例明显高于非ROSE组和瑞氏染色组,差异有统计学意义(P<0.05)。ROSE检测和瑞氏染色检测的诊断价值明显高于非ROSE检测(ROSE检测vs非ROSE检测:Z=3.95,P<0.05;瑞氏染色检测vs非ROSE检测:Z=3.87,P<0.05;ROSE检测vs瑞氏染色检测:Z=0.46,P>0.05)。ROSE组并发症发生率明显低于非ROSE组和瑞氏染色组,ROSE组和瑞氏染色组诊断费用明显少于非ROSE组,差异均有统计学意义(P<0.05)。结论:经支气管镜黏膜活检后ROSE对管腔浸润型肺癌诊断的临床价值高,其操作简便、快速,值得临床推广。

Objective:To compare the clinical value of rapid on-site evaluation(ROSE)and Wright’s staining after bronchoscopy mucosal biopsy in the diagnosis of luminal infiltrating lung cancer.Method:A total of 60 patients with lung cancer who underwent transbronchoscope mucosal biopsy in our department from January 2019 to April 2020 were selected as the research objects,and they were divided into ROSE group(n=25),non-ROSE group(n=16)and Wright’s staining group(n=19)according to different examination methods.The positive rate,sensitivity and specificity,complication rate and diagnosis cost of luminal infiltrating lung cancer in three groups were compared.Result:The positive rates of pathological examination of invasive lung cancer in Rose Group,non Rose Group and Wright’s staining group were 64.00%,31.25%and 52.63%,respectively.The positive rate of pathological examination in Rose Group was significantly higher than those in non Rose Group and Wright’s staining group(P<0.05).The diagnostic value of ROSE test and Wright’s staining test were significantly higher than that of non-ROSE test(ROSE test vs non-ROSE test:Z=3.95,P<0.05;ROSE test vs non-ROSE test:Z=3.87,P<0.05;ROSE test vs Wright’s staining test:Z=0.46,P>0.05).The incidence of complications in ROSE group was significantly lower than those in non-ROSE group and Wright’s staining group,the diagnostic costs in ROSE group and Wright’s staining group were significantly less than that in non-ROSE group,the differences were statistically significant(P<0.05).Conclusion:After bronchoscopic mucosal biopsy,ROSE has a high clinical value in the diagnosis of luminal infiltrative lung cancer.The operation is simple and fast,and it is worthy of clinical promotion.