血必净注射液对急性重症胰腺炎的治疗效果

Therapeutic Effect of Xuebijing Injection on Acute Severe Pancreatitis

目的探讨血必净注射液对急性重症胰腺炎患者的疗效及安全性。方法选择2016年10月—2018年10月医院接诊的急性重症胰腺炎患者78例,按照患者身份证号码最后一位单、双号分为对照组和观察组,每组39例,对照组采用以奥曲肽和乌司他丁为主的常规西医治疗策略,观察组在对照组治疗方法的基础上使用血必净注射液,对比两组治疗前后的血清C反应蛋白(CRP)、血清淀粉酶、脂肪酶水平。对比两组的谵妄发生率,机械通气维持时间,ICU停留时间。对比两组治疗前后的生活质量和握力。对比两组的治疗效果。结果在治疗后,两组患者的血清CRP、血清淀粉酶、脂肪酶水平均降低(t=35.590、39.965、35.911、54.018、49.992、41.792,P<0.05),在治疗后的组间比较中,观察组的血清CRP、血清淀粉酶、脂肪酶水平均低于对照组(t=34.820、20.333、22.651,P<0.05),观察组的谵妄发生率,机械通气维持时间,ICU停留时间均低于对照组(χ^2=4.522,t=7.358、12.549,P<0.05),在治疗后,两组患者的生活质量评分和握力值均增高(t=-8.313、-12.761、-13.675、-25.175,P<0.05),在治疗后,观察组的生活质量评分和握力值均高于对照组(t=-4.475、-9.424,P<0.05),观察组的治疗效果优于对照组(Z=2.499,P<0.05),对照组发生不良反应的总人数比例高于对照组(χ^2=14.821,P<0.05)。结论使用血必净注射液治疗急性重症胰腺炎患者,可以降低C反应蛋白、血清淀粉酶和脂肪酶的水平,缩短治疗时间,提升生活质量和治疗效果,降低不良反应。

Objective To explore the therapeutic effect of Xuebijing Injection on acute severe pancreatitis.Methods Seventy-eight patients with acute severe pancreatitis were treated between October 2016 and October 2018 at the Hospital.According to the last number of the patient ID,they were divided into the control group and the observation group,and each group had 39.The control group was treated with octreotide plus ulinastatin on a routine basis.The patients in the observation group were treated with Xuebijing Injection on the basis of the treatment methods of the control group.The levels of C-reactive protein(CRP),amylase and lipase in serum were compared between the two groups before and after treatment.The incidence of deliration,the mechanical ventilation maintenance time and the ICU stay time were compared between the two groups.The quality of life and grip strength of the two groups before and after treatment were compared.The therapeutic effects of the two groups were compared.Results After treatment,the levels of CRP,amylase and lipase in serum were decreased in both groups(t=35.590,39.965,35.911,54.018,49.992,41.792,P<0.05).In the comparison between the groups after treatment,the levels of CRP,amylase and lipase in serum in the observation group were lower than those in the control group(t=34.820,20.333,22.651,P<0.05).The incidence of deliration in the observation group,the duration of mechanical ventilation and the ICU stay time were lower than those in the control group(χ^2=4.522,t=7.358,12.549,P<0.05).After treatment,the quality of life score and grip strength of both groups were increased(t=-8.313,-12.761,-13.675,-25.175,P<0.05).The quality of life score and grip strength of the observation group were higher than those of the control group(t=-4.475,-9.424,P<0.05).The therapeutic effect of the observation group was better than that of the control group(z=2.499,P<0.05).The proportion of the total number of adverse reactions in the control group was higher than that of the control group(χ^2=14.821,P<0.05).Conclusion Xuebijing Injection can reduce the levels of C-reactive protein,amylase and lipase in serum,shorten treatment time,improve quality of life and therapeutic effect,and reduce adverse reactions when treating patients with acute severe pancreatitis.