摘要
巨噬细胞是人体重要的固有免疫细胞之一,有高度异质性和可塑性,在不同微环境刺激下可极化为M1型和M2型。巨噬细胞M1/M2表型与多种疾病的病理过程相关,但具体机制尚不明确。本文旨在对与其相关的疾病,如肿瘤、代谢性疾病、炎症性疾病进行描述,突出M1/M2极化稳态平衡在疾病中的重要作用,为临床治疗提供新靶点及方向。
Macrophages are one of the most important innate immune cells in human,which have high heterogeneity and plasticity.According to different micro-environmental stimuli conditions,macrophage polarization can be divided into M1 and M2 subsets.The M1/M2 phenotype of macrophages is related to the pathological process of various diseases,but the molecular mechanisms have not yet been elucidated.This article reviews macrophage polarization and the related diseases,such as tumors,metabolic diseases,inflammatory diseases,highlights the important role of M1/M2 balance,and provides a new target and direction for clinical treatment.
作者
周琦
孙慧娟
于栋华
刘树民
ZHOU Qi;SUN Hui-juan;YU Dong-hua;LIU Shu-min(Research Institute of Chinese Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Graduate School,Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2020年第11期1502-1506,共5页
Chinese Pharmacological Bulletin
基金
黑龙江省博士后科研启动金(No LRB146914)
黑龙江中医药大学杰出青年培育金(No 2019JC06)
哈尔滨市应用技术研究与开发项目(青年后备人才B类)(No 2017RAQXJ215)
黑龙江省教育厅高校青年创新人才项目(No 051599)
国家自然科学基金青年项目(No 81803871)。
关键词
巨噬细胞极化
肿瘤
糖尿病
肥胖
牙周炎
骨关节炎
类风湿关节炎
macrophage polarization
tumor
diabetes
obesity
periodontitis
osteoarthritis
rheumatoid arthritis
