硫酸镁注射液直接泵入在子痫前期治疗中的临床应用

Clinical application of directly pumped magnesium sulfate injection in the treatment of preeclampsia

目的:探讨硫酸镁注射液直接泵入在子痫前期治疗中的临床应用。方法:收集本院2014年1月-2020年2月住院的子痫前期患者病例共80例,将2014年1月-2017年1月收治的40例采用传统硫酸镁注射液加入液体中静滴的患者作为对照组,将2018年9月-2020年2月收治的40例采用硫酸镁注射液直接泵入的患者作为研究组。对比两组患者治疗前后肾功能指标及并发症。结果:两组治疗6个月后24 h尿蛋白定量(24 h UP)、血肌酐(Scr)、血尿酸(UA)和血尿素氮(BUN)均较治疗前降低,且研究组比对照组低,差异具有统计学意义(P<0.05);相比对照组,研究组并发症发生率略低,但差异无统计学意义(P>0.05)。结论:硫酸镁注射液不稀释使用微量泵直接泵入,可以更好的管理液体平衡,改善肾功能,未增加疾病并发症,且不影响降压效果,值得借鉴。

Objective:To investigate the clinical application of directly pumped magnesium sulfate injection in the treatment of preeclampsia.Methods:80 cases of preeclampsia patients hospitalized in our hospital from January 2014 to February 2020 were collected.40 cases of patients who were treated with treated with traditional magnesium sulfate injection by intravenous drip from January 2014 to January 2017 were selected as the control group,while the other 40 patients(from September 2018 to February 2020)who were given magnesium sulfate injection by directly pumping were selected as the study group.The renal function indexes and complications before and after treatment were compared between the two groups.Results:After 6 months of treatment,24-hour urine protein(24 hUP),serum creatinine(Scr),blood uric acid(UA)and blood urea nitrogen(BUN)of the two groups were lower than those before treatment,the difference was statistically significant(P<0.05).Compared with the control group,the incidence of complications in the study group was slightly lower,but the difference was not statistically significant(P>0.05).Conclusion:Directly pumping of magnesium sulfate injection without dilution can better manage liquid balance,improve renal function,without increasing disease complications,and does not affect the antihypertensive effect,which is worthy of reference.