二甲双胍联合孕激素治疗有生育要求早期子宫内膜癌患者的疗效观察

Efficacy of metformin combined with progesterone in early endometrial cancer patients with fertility requirements

目的探讨二甲双胍联合孕激素治疗有生育要求早期子宫内膜癌患者的临床效果。方法选取2017年3月至2020年3月间中国人民解放军空军第九八六医院收治的60例有生育要求的早期子宫内膜癌患者为研究对象,根据治疗方法不同进行分组,其中,采用醋酸甲羟孕酮分散片治疗的30例患者纳入对照组,在醋酸甲羟孕酮分散片治疗基础上给予二甲双胍治疗的30例患者纳入观察组。比较两组患者的治疗效果、PTEN基因表达情况、体质量指数变化情况、妊娠情况及满意度。结果观察组患者的有效率为71.7%,高于对照组患者的50.9%,差异有统计学意义(P<0.05)。治疗前,两组患者的体质量指数和PTEN基因表达比较,差异无统计学意义(P>0.05)。治疗后,观察组患者的体质量指数低于治疗前和对照组,差异有统计学意义(P<0.05);PTEN基因表达高于治疗前和对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的妊娠成功率和满意率均高于对照组,差异均有统计学意义(均P<0.05)。结论二甲双胍联合孕激素治疗有生育要求的早期子宫内膜癌效果较好,可降低患者的体质量指数,提高治疗后的妊娠率、满意度及PTEN基因表达。

Objective To study the efficacy of metformin combined with progesterone in early endometrial cancer patients with fertility requirements.Methods A total of 60 patients with early endometrial cancer with fertility requirements who were admitted to Chinese People's Liberation Army Air Force 986 Hospital from March 2017 to March 2020 were selected as research subjects.They were divided into two groups by random number table method with 30 patients in each group.The observation group was given metformin plus medroxyprogesterone acetate dispersible tablets and the control group received medroxyprogesterone acetate dispersible tablets.The treatment efficacy,expression of PTEN gene,body mass index,pregnancy status and satisfaction were compared between the two groups.Results The efficacy rate was 71.7%in the observation group which was significantly higher than 50.9%of the control group(P<0.05).There was no significant difference in body mass index and expression of PTEN between the two groups before treatment(P>0.05).After the treatment,body mass index was significantly lower in the observation group than in the control after treatment(P<0.05).However,the expression of PTEN was significantly higher in the observation group than that before the treatment and the control after treatment(P<0.05).The success rate of a pregnancy and satisfaction rate were significantly higher in the observation group than in the control group(P<0.05).Conclusion Metformin combined with progesterone shows efficacy in the treatment of patients with early endometrial cancer with fertility requirements,which can reduce the body mass index,improve pregnancy rate and satisfaction after treatment and increase the expression of PTEN gene.