帕金森病合并不宁腿综合征研究进展

Advance in Parkinson′s disease with restless legs syndrome

不宁腿综合征是帕金森病常见的非运动症状,但其重要性往往被忽视。有关帕金森病合并不宁腿综合征的临床研究结论不一。文中从发病机制、流行病学、症状学、遗传学与生物标志物、影像学及治疗等角度对帕金森合并不宁腿综合征的临床研究进行综述,以期提高临床医生对于二者共病的认识。

Restless legs syndrome is one of the common non-motor symptoms of Parkinson′s disease.Previous studies on Parkinson′s disease with comorbid restless legs syndrome generated mixed results.This article reviews the studies on Parkinson′s disease with restless legs syndrome on aspects of its pathophysiology,epidemiology,clinical symptoms,genetics and biomarkers,radiology and treatment,aiming to provide physicians a comprehensive understanding on the characteristics of two entities.