沙库巴曲缬沙坦抑制心脏重构的研究进展

Research progress on the inhibition of cardiac remodeling by Sacubitril/Valsartan

心脏重构是心血管疾病发生、发展的重要病理生理基础,与患者预后关系密切。沙库巴曲缬沙坦(LCZ696)是一种血管紧张素受体脑啡肽酶抑制剂,可同时作用于肾素-血管紧张素-醛固酮系统(RAAS)和利钠肽系统,主要用于治疗射血分数降低的心力衰竭。在不同类型的心血管疾病中,与肾素-血管紧张素系统抑制剂(RASI)比较,LCZ696能够显著抑制心脏重构,改善心功能及心血管病预后。本文就LCZ696对心脏重构抑制作用的机制及研究现状作一综述。

Cardiac remodeling is an important pathophysiological basis for the occurrence and development of cardiovascular disease and is closely related to the prognosis of patients.LCZ696 is an angiotensin receptor neprilysin inhibitor,which acts on both renin-angiotensin-aldosterone system(RAAS)and natriuretic peptide system.It is mainly used in the treatment of heart failure with decreased ejection fraction.Recent studies have shown that compared with reninangiotensin system inhibitor(RASI),LCZ696 can significantly inhibit cardiac remodeling and improve cardiac function and prognosis in different types of cardiovascular diseases.This article reviews the mechanism and research status of the inhibitory effect of LCZ696 on cardiac remodeling.