摘要
糖尿病是一种慢性非传染性疾病,严重威胁着人类的健康,目前治疗糖尿病的方法主要以服用降糖药物为主,具有一定的副作用。动物多糖广泛存在动物产品中,具有良好的降血糖功效且毒性低、副作用小。本文对近年来具有降血糖活性的动物多糖进行了总结,重点阐述了动物多糖控制胰岛素及胰岛β细胞、调节关键酶活性、改善糖代谢、调节关键蛋白表达、改善肝脏氧化应激水平等降糖作用机制。
Diabetes is a chronic non-communicable disease, which seriously threatens human health. The current treatment of diabetes is mainly based on taking hypoglycemic drugs, but it has certain side effects. Animal polysaccharides are distributed in almost all animal tissues and organs. They have been extensively used in the field of medicine and health products, because of their good hypoglycemic effect, low toxicity and few side effects. This article summarized the animal polysaccharides with hypoglycemic studied worldwide in recent years, focusing on the mechanism of them in controlling insulin and islet β cells, regulating key enzyme activities, improving glucose metabolism, regulating key protein expression and improving liver oxidative stress level.
作者
顾龙玥
孙晓晶
初侨
朱文卿
李利
郑振佳
GU Long-Yue;SUN Xiao-Jing;CHU Qiao;ZHU Wen-Qing;LI Li;ZHENG Zhen-Jia(Key Laboratory of Food Processing Technology and Quality Control in Shandong Province,College of Food Science and Engineering,Shandong Agricultural University,Tai’an 271018,China;Shandong Medical College,Jinan 250002,China;China National Institute of Standardization,Beijing 100191,China;Changyi City Fishery Technology Promotion in Shandong Province Station,Weifang 261300,China)
出处
《食品安全质量检测学报》
CAS
2020年第21期7674-7683,共10页
Journal of Food Safety and Quality
基金
山东省高等学校青创人才引育计划项目
山东省泰山产业领军人才工程高效生态农业创新类计划项目(LJNY201705)
中央级公益性科研院所基本科研业务费(562018Y-5950)。
关键词
动物多糖
糖尿病
降血糖
作用机制
animal polysaccharides
diabetes
hypoglycemic
mechanism
