血必净联合盐酸氨溴索对社区获得性重症肺炎的疗效观察

Clinical Observation of Xuebijing Combined with Ambroxol Hydrochloride in the Treatment of Community Acquired Severe Pneumonia

目的研究血必净注射液联合盐酸氨溴索对社区获得性重症肺炎患者血气分析指标和血清炎性因子的影响。方法选取2018年1月至2020年7月在我院收治的社区获得性重症肺炎患者80例,随机分为对照组(40例,常规基础治疗+盐酸氨溴索治疗)、观察组(40例,常规基础治疗+血必净注射液联合盐酸氨溴索治疗)。治疗2 w后,对比两组患者的临床总有效率、退热时间、住院时间、血气分析指标及血清炎性因子指标。结果与对照组80.00%(32/40)相比,观察组临床总有效率97.50%(39/40)更高(P<0.05);两组患者治疗后氧分压(PaO 2)、氧饱和度(SaO 2)、酸碱度(pH)水平均较治疗前增高(P<0.05),且观察组较对照组更高(P<0.05),而二氧化碳分压(PaCO 2)水平较治疗前降低(P<0.05),且观察组较对照组更低(P<0.05);观察组退热时间、住院时间均短于对照组(P<0.05)。治疗后两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)、高迁移率族蛋白(HMGB-1)水平较治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。对比两组不良反应无差异(P>0.05)。结论采用血必净注射液联合盐酸氨溴索社区获得性重症肺炎可获得较好的疗效,可改善患者血气分析指标和炎性因子水平。

Objective To study the effect of Xuebijing injection combined with ambroxol hydrochloride on blood gas analysis and serum inflammatory factors in patients with community acquired severe pneumonia.Methods 80 patients with community acquired severe pneumonia who were admitted to our hospital from January 2018 to July 2020 were selected and randomly divided into the control group(40 cases,treated with conventional therapy and ambroxol hydrochloride)and the observation group(40 cases,treated with conventional therapy and Xuebijing injection combined with ambroxol hydrochloride).After 2 weeks treatment,total effective rate,defervescence time,hospitalization time,blood gas analysis indexes and serum inflammatory factor indexes of the two groups were compared.Results Compared with 80.00%(32/40)in the control group,97.50%(39/40)of total effective rate in the observation group was higher(P<0.05).The levels of partial pressure of oxygen(PaO 2),oxygen saturation(SaO 2),degree of acid or alkali(pH)of patients in the two groups were higher than those before treatment(P<0.05),and the data of observation group was higher than those of the control group(P<0.05).Partial pressure of carbon dioxide(PaCO 2)levels was lower than that before treatment(P<0.05),and the data of the observation group was lower than those of the control group(P<0.05).The defervescence time and hospitalization time of the observation group were shorter than those of the control group(P<0.05).After treatment,the levels of IL6(IL-6),tumor necrosis factor-α(TNF-α),procalcitonin(PCT)and high mobility group protein(HMGB-1)in the two groups were lower than those before treatment(P<0.05),and the data of the observation group was lower than those of the control group(P<0.05).There was no difference in adverse reaction between the two groups(P>0.05).Conclusion Xuebijing injection combined with ambroxol hydrochloride is effective in the treatment of community acquired severe pneumonia,which can improve the blood gas analysis and inflammatory factors.