摘要
倍半萜类化合物是苍术属植物的主要活性成分之一,从苍术属植物根茎中分离得到的倍半萜类化合物按骨架类型可分为桉叶烷型、愈创木烷型、香根螺烷型和艾里莫酚烷型4种,以桉叶烷型为主。苍术属倍半萜类化合物具有广泛的生物活性,包括抗炎、抗肿瘤、保护神经系统、保肝、抗菌和抗病毒等活性。总结了苍术属植物中倍半萜类化合物化学成分的结构特点和生物活性,为该属植物深度开发利用提供参考。
Sesquiterpenes are one of the main active components of Atractylodes.According to the skeleton type,sesquiterpenes isolated from the rhizome of Atractylodes can be divided into four types:eudesmane-type,guaiane-type,spirovetivane-type and eremophilane-type,eudesmane-type was the main type.Sesquiterpenes of Atractylodes have a wide range of biological activities,including anti-inflammatory,anti-tumor,nervous system protection,liver protection,antibacterial and antiviral activities.The structural characteristics and biological activities of sesquiterpenes in Atractylodes are summarized in this paper,in order to provide reference for further development and utilization of Atractylodes.
作者
王艺萌
王知斌
孙延平
杨炳友
匡海学
WANG Yi-meng;WANG Zhi-bin;SUN Yan-ping;YANG Bing-you;KUANG Hai-xue(Key Laboratory of Basis and Application Research of North Medicine,Ministry of Education,Heilongjiang Provincial Key Laboratory of Traditional Chinese Medicines and Effective Substance Basis of Natural Medicines,Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第1期299-309,共11页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金面上项目(81973439)
国家自然科学基金面上项目(81872979)
国家自然科学基金资助项目(81803686)
黑龙江省科学基金项目(H2018056)
黑龙江省博士后科研启动资助金资助项目(LBH-Q16214)
黑龙江中医药大学“优秀创新人才支持计划”科研项目(2018RCD03)
黑龙江中医药大学校科研基金资助项目(201504)。
关键词
苍术属
倍半萜
桉叶烷型
愈创木烷型
香根螺烷型
艾里莫酚烷型
抗炎
抗肿瘤
保护神经系统
保肝
抗菌
抗病毒
Atractylodes DC.
sesquiterpenes
eudesmane-type
guaiane-type
spirovetivane-type
eremophilane-type
anti-inflammation
anti-tumor
nervous system protection
liver protection
antibacterial
antiviral
