葆宫止血颗粒应用于药物流产后患者的临床疗效评价

Evaluation of the clinical efficacy of Baogong Zhixue Granules in patients after medical abortion

目的探索中药制剂葆宫止血颗粒对药物流产后患者临床症状改善、血液动力学指标及性激素水平的影响。方法选取2015年6月至2019年12月于丽水中医院接受药物流产的76例患者作为研究对象,将患者随机分为试验组与对照组,各38例。试验组予以抗感染与葆宫止血颗粒治疗,对照组仅予以抗感染治疗。观察并比较两组患者的临床症状改善情况、血流动力学指标及性激素水平。结果试验组临床症状改善明显,其显效、有效及总有效占比显著高于对照组(χ^(2)值分别为4.54、4.28、5.02,均P<0.05),差异具有统计学意义。试验组的全血黏度、血浆黏度、红细胞压积与血沉数值均显著低于对照组(t值分别为2.38、2.19、2.32、2.20,均P<0.05),试验组的雌二醇、孕酮、卵泡刺激素以及垂体泌乳素水平显著低于对照组(t值分别为2.47、2.16、2.30、2.27,均P<0.05)。结论葆宫止血颗粒对药物流产后阴道出血等临床症状具有较好的改善作用,可促进子宫复旧,加速宫内残留物排出,调节药物流产后患者的凝血功能及激素水平,其临床疗效良好,适宜临床推广。

Objective To explore the effects of Baogong Zhixue Granules,a kind of traditional Chinese medicine,on the improvement of clinical symptoms,hemodynamic indicators and the levels of sex hormone in patients after medical abortion.Methods A total of 76 patients who underwent medical abortion at Lishui Traditional Chinese Medicine Hospital from June 2015 to December 2019 were selected as the research objects and randomly divided into the test group and the control group,with 38 cases in each group.The cases in the test group were treated with antibiotic and Baogong Zhixue Granules,and the cases in the control group were only treated with antibiotic.The improvement of clinical symptoms,hemodynamic indicators and the levels of sex hormone of the two groups were observed and compared.Results The clinical symptoms of the test group were significantly improved,the proportion of markedly effective improvement,effective improvement and total effective improvement on the clinical symptom in the test group were significantly higher than those in the control group(χ^(2)=4.54,4.28 and 5.02,respectively,all P<0.05).The values of whole blood viscosity,plasma viscosity,hematocrit,and erythrocyte sedimentation rate of the test group were significantly lower than those of the control group(t=2.38,2.19,2.32 and 2.20,respectively,all P<0.05).And the levels of estradiol,progesterone,follicle-stimulating hormone and pituitary prolactin of the test group were significantly lower than those of the control group(t=2.47,2.16,2.30,and 2.27,respectively,all P<0.05).Conclusion Baogong Zhixue Granules have a good effect on the improvement of clinical symptom for patients after medical abortion,which could promote uterine involution,accelerate the elimination of residual substances in uterus,and regulate the blood coagulation function and sex hormone levels.Therefore,Baogong Zhixue Granules is suitable for clinical popularization for its good clinical efficacy.