尼卡地平联合拉贝洛尔对妊娠高血压患者血压及血清基质金属蛋白酶-9、水通道蛋白-9水平的影响

Effect of Nicardipine Combined with Labetalol on Blood Pressure and Serum Matrix Metalloproteinase-9,Aquaporin-9 Levels in Patients with Gestational Hypertension

目的探讨尼卡地平联合拉贝洛尔对妊娠高血压患者血压及血清基质金属蛋白酶-9(MMP-9)、水通道蛋白-9(AQP-9)水平的影响。方法选取2018年3月至2020年3月营口市妇产儿童医院收治的88例妊娠高血压患者作为研究对象,按随机数字表法分为试验组与对照组,各44例。对照组使用拉贝洛尔治疗,在此基础上,试验组加用尼卡地平片治疗。比较两组血压、血清MMP-9、AQP-9水平和不良反应发生情况。结果治疗后,试验组舒张压(DBP)、收缩压(SBP)及血清MMP-9、AQP-9水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论尼卡地平联合拉贝洛尔治疗妊娠高血压能有效降低血压和血清MMP-9、AQP-9水平,不会增加不良反应发生。

Objective To investigate the effect of nicardipine combined with labetalol on blood pressure and serum levels of matrix metalloproteinase-9(MMP-9)and aquaporin-9(AQP-9)in patients with gestational hypertension.Methods A total of 88 patients with gestational hypertension in Yingkou Maternity and Children's Hospital from March 2018 to March 2020 were selected as the research objects and were randomly assigned into an experimental group(n=44)and a control group(n=44)according to random number table.The control group was treated with labetalol,and the experimental group was treated with nicardipine tablets plus labetalol.Blood pressure,serum MMP-9,aqp-9 levels and adverse reactions were compared between the 2 groups.Results After treatment,Diastolic blood pressure(DBP),systolic blood pressure(SBP),serum MMP-9,AQP-9 levels in the experimental group were lower than those in the control group,the difference was statistically significant(P<0.05);there was no significant difference in adverse reactions between the 2 groups(P>0.05).Conclusion Nicardipine combined with labetalol in the treatment of pregnancy hypertension can effectively reduce blood pressure and serum MMP-9,AQP-9 levels,without increasing the incidence of adverse reactions.