基于“肺阳虚”探讨哮喘寒饮蕴肺证病机并从细胞自噬探讨其病理机制

Based on“lung yang deficiency”discussing pathogenesis of asthma with syndrome of cold fluid retention in lung and its pathological mechanism from the perspective of autophagy

从五行学说、藏象学说等角度分析历代医家多言"肺气"而少言"肺阳"的原因,并探讨"肺阳""肺阳虚"与哮喘寒饮蕴肺证病理机制的联系以及"肺阳虚"状态对哮喘寒饮蕴肺证的影响。据此提出"肺阳虚"可以抑制机体的自噬水平,使得气道炎症水平升高进而导致哮喘寒饮蕴肺证的发病这一科学假设。

From the perspectives of five elements theory and visceral state theory,this paper analyzes the reasons why doctors in past dynasties talked more about"lung qi"than"lung yang".And it explores the relationship between"lung yang","lung yang deficiency"and the pathological mechanism of asthma with syndrome of cold fluid retention in lung,as well as the influence of"lung yang deficiency"state on asthma with syndrome of cold fluid retention in lung.Accordingly,it is proposed that"lung yang deficiency"can inhibit the autophagy level of the body and increase the level of airway inflammation,which leads to the pathogenesis of asthma with syndrome of cold fluid retention in lung.