经颅直流电刺激下健康成人肌肉力量及耐力表现的Meta分析

Effects of transcranial direct current stimulation on muscle strength and endurance performance in healthy adults:a systematic review and meta-analysis

目的:目前经颅直流电刺激在运动表现方面的研究尚处于起步阶段,且已有的研究结论存在不一致性。文章旨在定量评价经颅直流电刺激对健康成人肌肉力量与耐力表现的影响,以期为应用新型神经电生理技术提高肌肉功能提供新证据。方法:通过检索Web of Science(WOS)、PubMed、Sport Discus、CNKI数据库,检索时限为建库至2019年10月,收集经颅直流电刺激对健康成人肌肉力量与耐力表现影响的随机对照试验研究。依据Cochrane系统评价手册,采用Review Manager 5.3软件对纳入文献进行方法学质量评价与合并效应量分析。结果:①共纳入15项随机对照试验,包含201名健康受试者;②Meta分析结果显示:相较于试验组,经颅直流电刺激干预对改善肌肉力量证据不足[I^(2)=47%,95%CI(-0.79,0.23),P=0.27>0.05,SMD=-0.28];③经颅直流电刺激刺激对改善耐力表现的功能优于对照组,合并效应量趋向于中等效应[I^(2)=57%,95%CI(0.10,0.76),P=0.01<0.05,SMD=0.43]。结论:提示经颅直流电刺激干预对力量的改善无统计学意义,但对提高耐力表现的效果总体趋于有效;建议实施更严格和广泛的试验研究,加强经颅直流电刺激神经生理机制探索。

OBJECTIVE:The up-to-now researches on the effect of transcranial direct current stimulation(tDCS)on exercise performance are in the initial phase,and the existing conclusions are inconsistent.This meta-analysis attempted to quantitatively evaluate the effect of tDCS on muscle strength and endurance performance of healthy adults,providing new evidence for new neuroelectrophysiological techniques as well as improving the muscle function.METHODS:To collect randomized controlled trial(RCT)studies regarding the effects of tDCS on muscle strength and endurance performance in healthy adults,the following databases were searched from inception to October 2019:Web of Science,PubMed,Sport Discus,and CNKI.According to the Cochrane Systematic Review Manual,Review Manager 5.3 software was used to evaluate the methodological quality of the literature included and to analyze the combined effect amount.RESULTS:A total of 15 RCTs involving 201 healthy subjects were included.The meta-analysis indicated that compared with the experimental group,tDCS intervention had insufficient evidence in improving muscle strength:I^(2)=47%,95%confidence interval[-0.79,0.23],P=0.27>0.05,standard mean difference=-0.28.Compared with the control group,the function of tDCS stimulation to improve the performance of endurance was more evident,and the combined effect amount tended to a medium effect:I^(2)=57%,95%confidence interval[0.10,0.76],P=0.01<0.05,and standard mean difference=0.43.CONCLUSION:tDCS intervention has no statistical significance in improving strength,but it is effective in improving endurance performance in general.More rigorous and extensive experimental researches are warranted to explore the tDCS neurophysiological mechanism.