桑葚化学成分、药理作用及质量标志物研究进展

Research progress on chemical constituents,pharmacological effects and quality markers of mulberry

桑葚为我国常用的药食同源类中药,主要化学成分为黄酮类、花色苷类、酚酸类和多糖类,具有保肝、抗氧化、抗炎、抗肿瘤、降血压等作用。中药成分多且复杂,采用单一指标作为质量标准的依据不太准确。本文对桑葚化学成分进行总结归纳,阐述桑葚的药理作用,并以此为基础,从亲缘性及特有性、传统药效、新的药效、传统药性、可测性,分析可作为其质量标志物(Q-marker)成分,推测桑葚多糖、花色苷类如矢车菊-3-葡萄糖苷和矢车菊-3-O-葡萄糖苷,以及白藜芦醇等成分可作为质量标志物成分。提出后续应聚焦桑葚多糖、花色苷类成分定性和定量的研究,对黄酮类、酚酸类等成分进行深入研究的建议,为桑葚质量标准的制订提供依据,为后续研究提供参考。

Mulberry is a traditional Chinese medicine commonly used in medicine and food in my country.Its main chemical components are flavonoids,anthocyanins,phenolic acids and polysaccharides.It has the functions of protecting liver,anti-oxidation,anti-inflammatory,anti-tumor,and lowering blood pressure and so on.Traditional Chinese medicine has many and complex components,and it is not accurate to use a single index as the basis for quality standards.Therefore,this article summarized the chemical constituents of mulberries,expounds the pharmacological effects of mulberries.Analysised its Q-marker components from the perspective of affinity and peculiarities,traditional medicinal effects,new medicinal effects,traditional medicinal properties,and measurability on the basis of its chemical constituents and pharmacological effects.It was speculated that mulberry polysaccharide,cyanidin-3-glucoside and cyanidin-3-O-glucoside,and resveratrol can be used as Q-markers.It is recommended that follow-up research should focus on qualitative and quantitative research of mulberry polysaccharides and anthocyanins,that and conduct in-depth research on flavonoids and phenolic acids to provide a basis for the formulation of mulberry quality standards and provide reference for subsequent research.