维生素C联合微生态制剂治疗肝硬化的疗效探析

Analysis of the Curative Effect of Vitamin C Combined with Microecological Agents in the Treatment of Liver Cirrhosis

目的探析维生素C联合微生态制剂治疗肝硬化的治疗效果。方法乙型肝炎肝硬化患者,共计122例,时间自2018年1—12月,随机分成甲(微生态制剂)、乙(维生素C+微生态制剂)组,每组各61例,评价疗效。结果甲组DNA、HBV转阴为40例,转阴率为65.57%(40/61)。乙组,DNA、HBV转阴为51例,转阴率为83.61%(51/61)。乙组DNA、HBV转阴率高于甲组,差异有统计学意义(χ^(2)=5.233,P=0.022)。两组治疗后AST指标,甲组(46.82±10.17)U/L,乙组(31.59±8.45)U/L;治疗后ALT指标,甲组(38.98±5.65)U/L,乙组(31.72±5.41)U/L;治疗后TBIL指标,甲组(29.86±5.26)μmol/L,乙组(21.65±5.49)μmol/L。两组肝纤维化指标比较,甲组治疗后HA为(159.86±20.13)ng/mL,乙组为(104.53±19.76)ng/mL;甲组治疗后PCⅢ为(13.93±1.75)ng/mL,乙组为(11.57±2.19)ng/mL;治疗后LN甲组为(123.72±15.81)ng/mL,乙组为(94.75±17.53)ng/mL;乙组肝功能指标、肝纤维化指标均低于甲组,差异有统计学意义(P<0.05)。结论对于肝硬化患者,予以维生素C联合微生态制剂治疗,疗效确切,值得推荐。

Objective To explore the therapeutic effect of vitamin C combined with probiotics in the treatment of liver cirrhosis.Methods A total of 122 patients with hepatitis B and liver cirrhosis,from January to December 2018,were randomly divided into A(microecological preparation)and B(vitamin C+microecological preparation)groups,each with 61 cases,and the efficacy was evaluated.Results In group A,40 cases of DNA and HBV turned negative,and the negative conversion rate was 65.57%(40/61).In group B,51 cases were negative for DNA and HBV,and the negative conversion rate was 83.61%(51/61).The negative conversion rate of DNA and HBV of group B was higher than that of group A,the difference was statistically significant(χ^(2)=5.233,P=0.022).The liver function indexes of the two groups for the treatment of AST,group A were(46.82±10.17)U/L and the group B were(31.59±8.45)U/L;after treatment,ALT indexes for group A was(38.98±5.65)U/L,and group B was(31.72±5.41)U/L;After treatment,TBIL indexes was(29.86±5.26)μmol/L in group A and(21.65±5.49)μmol/L in group B.Comparison of liver fibrosis indexes between the two groups.After treatment,HA was(159.86±20.13)ng/mL in group A,(104.53±19.76)ng/mL in group B;after treatment,PCⅢgroup A was(13.93±1.75)ng/mL,group B was(11.57±2.19)ng/mL;after treatment,LN group A was(123.72±15.81)ng/mL,group B was(94.75±17.53)ng/mL;the liver function indexes and liver fibrosis indexes of group B were lower than those of group A,the difference was statistically significant(P<0.05).Conclusion For patients with liver cirrhosis,vitamin C combined with probiotics is effective and worthy of recommendation.