摘要
结核病是由结核分枝杆菌(Mtb)所致的以呼吸系统感染为主的慢性传染病,潜伏结核感染(LTBI)高危者是结核病预防的关键人群,针对LTBI的早期诊断和高危人群的预防性治疗能有效减少活动性结核病(ATB)发病率。但现有的诊断方法诊断LTBI的特异度较低,因此建立快速、敏感、高效的LTBI诊断方法仍是目前结核病控制工作中面临的重要难题。本文就LTBI相关蛋白抗原的研究进展进行综述,以为LTBI的诊断提供参考。
Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis(Mtb),which is mainly infected in the respiratory system.People at high risk of latent tuberculosis infection(LTBI)are the key population for tuberculosis prevention.Early diagnosis and preventive treatment for high-risk LTBI can effectively reduce the incidence of active tuberculosis(ATB).However,the existing diagnostic methods have low specificity for detecting LTBI,and the establishment of a fast,sensitive and efficient LTBI diagnostic method has becoming an important problem in the tuberculosis control field.Searching for specific antigens with diagnostic value for LTBI has becoming a current research hotspot.This paper mainly reviewed the research progress of LTBI related protein antigens,in order to provide a reference for the diagnosis of LTBI.
作者
沈瑶
陈玲
SHEN Yao;CHEN Ling(Tuberculosis Division,Second Department of Respiratory and Critical Care Medicine,the Affiliated Hospital of Zunyi Medical University,Zunyi 563003,China)
出处
《实用心脑肺血管病杂志》
2021年第4期25-31,共7页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
国家自然科学基金资助项目(81760003)。
关键词
医院
慢性病
结核分枝杆菌
潜伏结核感染
蛋白抗原
免疫学
综述
Hospitals,chronic disease
Mycobacterium tuberculosis
Latent tuberculosis infection
Protein antigen
Immunology
Review
