长期小剂量阿奇霉素对慢性阻塞性肺疾病稳定期患者的免疫调节作用研究

Study the immunomodulatory effects with long-term low-dose Azithromycin for stable phase of chronic obstructive pulmonary disease patients

目的:分析予以稳定期慢阻肺患者长期低剂量阿奇霉素的免疫调节作用。方法:将2017.01-2020.10院内收治的稳定期慢阻肺共72例患者为研究对象,依据随机数表法分成对照组(予以常规治疗)和观察组(于对照组前提下加以长期小剂量的阿奇霉素口服)分别36例,统计并比较两组治疗有效率、治疗前后6min行走路程、呼吸困难评分与血清白细胞介素-17(IL-17)及白细胞介素-10(IL-10)水平情况。结果:观察组于有效率方面超出对照组(P<0.05)。治疗后,观察组于呼吸困难评分方面低于对照组,于6min行走路程方面长于对照组(P<0.05)。治疗后,观察组于IL-17水平方面低于对照组,于IL-10水平方面超出对照组(P<0.05)。结论:予以稳定期慢阻肺患者长期低剂量阿奇霉素效果确切,能改善其各项症状,提升其肺部功能,对免疫系统起到一定的调节作用,减轻气道的炎症,值得采用。

Objective:To study the immunomodulatory effects with long-term low-dose Azithromycin for stable phase of chronic obstructive pulmonary disease patients.Methods:A total of 72 stable phase of chronic obstructive pulmonary disease patients treated from January 2017 to October 2020 in our hospital were selected as research subjects.According to random number table,patients were divided into control group(36 cases)and observation group(36 cases).The control group took the routine therapy;on the basis of the former,the observation group orally took the long-term low-dose Azithromycin.The effective treatment rate,6-minute walk distance and dyspnea rating scores and serum interleukin-17(IL-17)and interleukin-10(IL-10)levels were counted.Results:The effective treatment rate in the observation group was obviously increased by comparison with control group(P<0.05);compared with control group,the dyspnea rating scores in the observation group were reduced while 6-minute walk distance was extended(P<0.05);compared with control group,serum IL-17 levels in the observation group were reduced while IL-10 levels were increased(P<0.05).Conclusion:The long-term low-dose Azithromycin is proven to be more effective,which can reduce the airway inflammation response and play the adjusting role in the improvements of clinical symptoms,pulmonary and immune function.It is worthy of application.