瑞舒伐他汀对老年高血压患者血管内皮功能及炎症反应的影响

Effect of Rosuvastatin on Vascular Endothelial Function and Inflammatory Response in Elderly Patients with Hypertension

目的探讨瑞舒伐他汀对高血压患者血管内皮功能和炎症反应的调节作用.方法选择2018年6月—2019年6月辽阳市第二人民医院收治的老年高血压患者80例,随机分为对照组和观察组各40例.对照组采用常规药物进行降压治疗,对照组在其基础上加用瑞舒伐他汀.比较两组患者治疗3个月后血管内皮功能和炎症反应改善状况.结果治疗后,血管内皮功能方面两组一氧化氮、一氧化氮合酶、非对称性二甲基精氨酸、内皮素-1、血管性血友病因子水平差异有统计学意义(P<0.05);炎症反应方面两组超敏C反应蛋白、肿瘤坏死因子-α和白介素-6水平差异有统计学意义(P<0.05).结论瑞舒伐他汀能够有效改善高血压患者血管内皮功能和炎症反应,有利于从血管调节角度发挥调节作用.

Objective To investigate the regulatory effect of rosuvastatin on vascular endothelial function and inflammatory response in patients with hypertension.Methods A total of 80 elderly patients with hypertension admitted to our hospital from June 2018 to June 2019 were randomly divided into control group and observation group with 40 cases in each group.The control group was treated with conventional drugs,and the observation group was treated with rosuvastatin on the basis of conventional drugs.The vascular endothelial function and inflammatory response were compared between the two groups after 3 months treatment.Results After treatment,the levels of NO,NOS,ADMA,ET-1 and vWF were significantly different between the two groups(P<0.05);the levels of hs CRP,TNF-αand IL-6 in the two groups were significantly different(P<0.05).Conclusion Rosuvastatin can effectively improve vascular endothelial function and inflammatory response in patients with hypertension,which is conducive to play a regulatory role from the perspective of vascular regulation.