注射用重组人促卵泡激素不同启动剂量对不孕患者性激素水平及获卵数的影响

Effects of Different Starting Doses of Gonafine on Sex Hormone Levels and Oocyte Retrieval in Infertile Women

目的探讨注射用重组人促卵泡激素不同启动剂量治疗不孕患者对性激素水平、获卵效果的影响。方法选取2017年8月至2019年8月就诊于云南九洲医院的不孕患者92例作为研究对象,按随机数字表法分为对照组与观察组,各46例。对照组予以大启动剂量注射用重组人促卵泡激素治疗,观察组采用小启动剂量注射用重组人促卵泡激素治疗。比较两组性激素水平、获卵效果及临床结局。结果两组促排卵前性激素水平比较,差异无统计学意义(P>0.05);观察组促排卵后促卵泡激素(FSH)为(1.71±0.26)IU/L,低于对照组的(2.34±0.42)IU/L,雌二醇(E_(2))为(4 012.36±516.84)ng/L,高于对照组的(3241.85±425.96)ng/L,差异有统计学意义(P<0.05);两组获卵数、成熟卵子数比较,差异无统计学意义(P>0.05);两组临床妊娠、轻度卵巢过度刺激综合征及多胎妊娠发生率比较,差异无统计学意义(P>0.05)。结论小启动剂量注射用重组人促卵泡激素可有效调节不孕患者性激素水平,取得与大剂量相当的获卵效果与临床妊娠率,利于减轻患者经济负担。

Objective To investigate the effects of different starting doses of gonafine on the levels of sex hormones, oocyte retrieval in infertile women. Methods A total of 92 infertility patients admitted to Jiuzhou Hospital in Yunnan from December 2017 to December 2019 were selected as the research objects and were randomly divided into 2 groups, with 46 cases in each group. The control group was treated with high starting dose of ganafine, and the observation group was treated with low starting dose of ganafine. The levels of sex hormone, oocyte retrieval effect and clinical outcome were compared between the 2 groups. Results There was no significant difference in sex hormone level between the 2 groups before ovulation induction(P>0.05);FSH after ovulation induction in observation group was(1.71±0.26)IU/L, which was lower than that in control group(2.34±0.42) IU/L, E_(2) was(4 012.36±516.84) PG/ml, which was higher than that of control group(3 241.85±425.96) pg/ml, the difference was statistically significant(P<0.05);there was no difference in the number of retrieved eggs and mature eggs between the 2 groups There was no significant difference in clinical pregnancy rate, mild ovarian hyperstimulation syndrome and multiple pregnancy rate between the 2 groups(P>0.05). Conclusion Low starting dose of gonafine can regulate the level of sex hormone in infertile patients, achieve the same effect of oocyte capture and clinical pregnancy rate as high dose, and can reduce the economic burden of patients.